CTIF, cap binding complex dependent translation initiation factor

CTIF, cap binding complex dependent translation initiation factor

• CTIF is a component of the CBP80 (NCBP1; MIM 600469)/CBP20 (NCBP2; MIM 605133) translation initiation complex that binds cotranscriptionally to the cap end of nascent mRNA. The CBP80/CBP20 complex is involved in a simultaneous editing and translation step that recognizes premature termination codons (PTCs) in mRNAs and directs PTC-containing mRNAs toward nonsense-mediated decay (NMD). On mRNAs without PTCs, the CBP80/CBP20 complex is replaced with cytoplasmic mRNA cap-binding proteins, including EIF4G (MIM 600495), and steady-state translation of the mRNAs resumes in the cytoplasm (Kim et al., 2009 [PubMed 19648179]).[supplied by OMIM, Dec 2009]

• Gene Synonyms (CBP80/20-dependent translation initiation factor, Gm672, KIAA0427,)
• NCBI Gene ID: 9811
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R259
  UNIPROT ID#>>O43310
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

cap binding complex dependent translation initiation factor interacts with:

• ataxin 7 like 2
  ATP synthase mitochondrial F1 complex assembly factor 2
  DEAD-box helicase 19A
  DEAD-box helicase 19B
  F-box and WD repeat domain containing 7
  HEXIM P-TEFb complex subunit 2
  hook microtubule tethering protein 1
  hook microtubule tethering protein 3
  MIF4G domain containing
  SPG21 abhydrolase domain containing, maspardin

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