4-1BB Bioassay, Propagation Model
Instructions for Use of Product(s)
J2332
Literature # TM551
The 4-1BB Bioassay, Propagation Model, is a bioluminescent cell-based assay that overcomes the limitations of existing assays and can be used to measure the potency and stability of ligands or agonist antibodies that bind and activate 4-1BB. The assay consists of a genetically engineered Jurkat T cell line that expresses human 4-1BB and a luciferase reporter driven by a response element that can respond to 4-1BB ligand/agonist antibody stimulation. The 4-1BB Effector Cells are provided in Cell Propagation Model (CPM) format, which includes cryopreserved cells that can be thawed, propagated and banked for long-term use.
Summary of Changes
The following changes were made to the 6/25 revision of this document:
1. Removed an expired patent statement and updated two other patent statements.
2. Changed Lumit to a registered trademark.
3. Revised text about the label in Section 3.
4. Added a third party trademark.
Revised 6/25.