CHN1, chimerin 1

CHN1, chimerin 1

• This gene encodes GTPase-activating protein for ras-related p21-rac and a phorbol ester receptor. It is predominantly expressed in neurons, and plays an important role in neuronal signal-transduction mechanisms. Mutations in this gene are associated with Duane's retraction syndrome 2 (DURS2). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]

• Gene Synonyms (N-chimaerin, A-chimaerin, Rho GTPase-activating protein 2, a2-chimaerin, alpha-chimerin, chimaerin 1, chimerin (chimaerin) 1, n-chimerin, ARHGAP2, CHN, DURS2, NC, RHOGAP2,)
• NCBI Gene ID: 1123
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P15882
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

chimerin 1 interacts with:

• ankyrin repeat and kinase domain containing 1
  chimerin 2
  C-terminal Src kinase
  cyclin dependent kinase 5 regulatory subunit 1
  erb-b2 receptor tyrosine kinase 2
  general transcription factor IIIC subunit 1
  glutamate receptor, ionotropic, NMDA2A (epsilon 1)
  HemK methyltransferase family member 1
  KRAS proto-oncogene, GTPase
  mitogen-activated protein kinase 1
  mitogen-activated protein kinase 8 interacting protein 2
  NCK adaptor protein 2
  Rac family small GTPase 1
  ribosomal protein S3A
  ring finger protein 123
  transforming growth factor beta receptor 1
  tripartite motif containing 25

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.