RAC1, Rac family small GTPase 1

RAC1, Rac family small GTPase 1

• The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

• Gene Synonyms (ras-related C3 botulinum toxin substrate 1, cell migration-inducing gene 5 protein, ras-like protein TC25, ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1), MIG5, MRD48, Rac-1, TC-25, p21-Rac1,)
• NCBI Gene ID: 5879
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P63000
  UNIPROT ID#>>A4D2P0
  UNIPROT ID#>>A4D2P1
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

Rac family small GTPase 1 interacts with:

• 3-hydroxyacyl-CoA dehydratase 3
  ADP ribosylation factor interacting protein 2
  ADP ribosylation factor like GTPase 2 binding protein
  ADP ribosylation factor like GTPase 4A
  ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
  ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
  BAG cochaperone 6
  BAR/IMD domain containing adaptor protein 2
  CAP-Gly domain containing linker protein 1
  CDC42 binding protein kinase gamma
  CDC42 small effector 1
  CDC42 small effector 2
  cell division cycle 23
  cilia and flagella associated protein 36
  citron rho-interacting serine/threonine kinase
  component of oligomeric golgi complex 5
  COPI coat complex subunit epsilon
  coronin 1C
  coronin, actin binding protein 1C
  cytoplasmic FMR1 interacting protein 1
  DAZ associated protein 1
  dedicator of cytokinesis 7
  dedicator of cytokinesis 8
  DEF6 guanine nucleotide exchange factor
  diaphanous related formin 3
  DNA polymerase alpha 2, accessory subunit
  DNA topoisomerase II alpha
  dual specificity phosphatase 23
  egl-9 family hypoxia inducible factor 3
  embryonic ectoderm development
  ENAH actin regulator
  filamin, beta
  formin 2
  formin homology 2 domain containing 1
  GIT ArfGAP 1
  H3 clustered histone 1
  HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
  histone deacetylase 7
  HPS4 biogenesis of lysosomal organelles complex 3 subunit 2
  huntingtin
  IQ motif and Sec7 domain ArfGEF 2
  IQ motif containing B1
  IQ motif containing GTPase activating protein 1
  IQ motif containing GTPase activating protein 2
  IQ motif containing GTPase activating protein 3
  isoprenylcysteine carboxyl methyltransferase
  kalirin RhoGEF kinase
  karyopherin subunit alpha 6
  keratin 40
  laccase domain containing 1
  large tumor suppressor kinase 1
  latent transforming growth factor beta binding protein 4
  leucine rich pentatricopeptide repeat containing
  leucine rich repeat kinase 2
  leucine zipper tumor suppressor 2
  LIM domain and actin binding 1
  MCF.2 cell line derived transforming sequence like
  membrane associated guanylate kinase, WW and PDZ domain containing 1
  methionyl aminopeptidase 2
  minichromosome maintenance complex component 3 associated protein
  myosin light chain 6B
  myosin XIX
  NADPH oxidase activator 1
  NCK associated protein 1
  neutrophil cytosolic factor 1
  nuclear receptor subfamily 2 group C member 2
  p21 (RAC1) activated kinase 4
  p21 (RAC1) activated kinase 5
  p21 (RAC1) activated kinase 6
  par-6 family cell polarity regulator alpha
  par-6 family cell polarity regulator beta
  par-6 family cell polarity regulator gamma
  peptide deformylase, mitochondrial
  phosphoserine aminotransferase 1
  pleckstrin homology and RhoGEF domain containing G2
  pleckstrin homology domain containing A4
  proteasome (prosome, macropain) subunit, beta type 5
  protein arginine methyltransferase 6
  protein inhibitor of activated STAT 3
  Rac family small GTPase 1
  Rac family small GTPase 3
  Rac/Cdc42 guanine nucleotide exchange factor 6
  ralA binding protein 1
  Rap1 GTPase-GDP dissociation stimulator 1
  Ras homolog, mTORC1 binding
  Ras protein specific guanine nucleotide releasing factor 1
  regulator of chromosome condensation 2
  RELB proto-oncogene, NF-kB subunit
  Rho GTPase activating protein 15
  Rho GTPase activating protein 17
  Rho GTPase activating protein 27
  Rho GTPase activating protein 31
  Rho GTPase activating protein 32
  Rho GTPase activating protein 33
  Rho GTPase activating protein 44
  Rho GTPase activating protein 8
  Rho guanine nucleotide exchange factor 25
  Rho guanine nucleotide exchange factor 4
  Rho guanine nucleotide exchange factor 7
  Rho/Rac guanine nucleotide exchange factor 2
  ribosomal protein L3
  ribosomal protein S6 kinase B1
  RNA binding motif protein X-linked
  SET nuclear proto-oncogene
  SH3 domain binding protein 1
  SH3 domain containing ring finger 1
  SH3 domain containing ring finger 1
  SH3 domain containing ring finger 2
  SH3 domain containing ring finger 3
  signal transducer and activator of transcription 1
  signal transducer and activator of transcription 3
  sorting nexin 31
  SOS Ras/Rac guanine nucleotide exchange factor 1
  splicing factor proline and glutamine rich
  SRC proto-oncogene, non-receptor tyrosine kinase
  staufen double-stranded RNA binding protein 1
  synaptojanin 2
  target of myb1 membrane trafficking protein
  TBC1 domain family member 3F
  tec protein tyrosine kinase
  TIAM Rac1 associated GEF 1
  TNF receptor associated factor 7
  TNF receptor superfamily member 12A
  TNF receptor superfamily member 1A
  toll interacting protein
  toll like receptor 2
  transaldolase 1
  transcription factor 7 like 2
  trio Rho guanine nucleotide exchange factor
  tubulin alpha 4a
  tumor necrosis factor
  ubiquitin C
  ubiquitin conjugating enzyme E2 M
  ubiquitin protein ligase E3B
  ubiquitin specific peptidase 6
  unk like zinc finger
  USH1 protein network component harmonin
  vascular cell adhesion molecule 1
  vav guanine nucleotide exchange factor 1
  vav guanine nucleotide exchange factor 2
  vav guanine nucleotide exchange factor 3
  von Willebrand factor
  WASP actin nucleation promoting factor
  WASP family member 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.