CRHR2, corticotropin releasing hormone receptor 2

CRHR2, corticotropin releasing hormone receptor 2

• The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011]

• Gene Synonyms (corticotropin-releasing factor receptor 2, CRF2 receptor, beta isoform, CRH receptor 2 variant B, CRH-R2, CRF-RB, CRF2, CRFR2, HM-CRF,)
• NCBI Gene ID: 1395
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A090N7T4
  UNIPROT ID#>>Q13324
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

corticotropin releasing hormone receptor 2 interacts with:

• corticotropin releasing hormone receptor 2
  mal, T cell differentiation protein like
  urocortin
  urocortin 2
  urocortin 3

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.