DFFB, DNA fragmentation factor subunit beta

DFFB, DNA fragmentation factor subunit beta

• Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of some of these variants has not been determined. [provided by RefSeq, Sep 2013]

• Gene Synonyms (DNA fragmentation factor subunit beta, DNA fragmentation factor 40 kDa subunit, DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase), caspase-activated DNase, caspase-activated deoxyribonuclease, caspase-activated nuclease, CAD, CPAN, DFF-40, DFF2, DFF40,)
• NCBI Gene ID: 1677
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q96P72
  UNIPROT ID#>>O76075
  UNIPROT ID#>>Q96P73
  UNIPROT ID#>>B4DZS0
  UNIPROT ID#>>Q96P74
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

DNA fragmentation factor subunit beta interacts with:

• cell death inducing DFFA like effector b
  COP9 signalosome subunit 5
  cullin 1
  cullin 2
  cullin 5
  cullin associated and neddylation dissociated 1
  DNA fragmentation factor subunit beta
  DNA topoisomerase II alpha
  heterogeneous nuclear ribonucleoprotein L
  leucine rich repeat containing 15
  mago homolog, exon junction complex subunit
  myristoylated alanine rich protein kinase C substrate
  NEDD8 ubiquitin like modifier
  neurofilament heavy
  nucleotide binding protein 1
  protein kinase cAMP-activated catalytic subunit beta
  protein kinase N2
  protein tyrosine phosphatase non-receptor type 13
  ubiquitin B

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