S1PR1, sphingosine-1-phosphate receptor 1

S1PR1, sphingosine-1-phosphate receptor 1

• The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

• Gene Synonyms (CD363, CHEDG1, D1S3362, ECGF1, EDG-1, EDG1, S1P1, sphingosine 1-phosphate receptor 1, S1P receptor 1, S1P receptor Edg-1, endothelial differentiation G-protein coupled receptor 1, endothelial differentiation, sphingolipid G-protein-coupled receptor, 1, sphingosine 1-phosphate receptor EDG1, sphingosine 1-phosphate receptor Edg-1,)
• NCBI Gene ID: 1901
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P21453
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

sphingosine-1-phosphate receptor 1 interacts with:

• 5-hydroxytryptamine receptor 1A
  5-hydroxytryptamine receptor 1D
  ADP ribosylation factor like GTPase 10
  cms1 ribosomal small subunit homolog
  C-type lectin domain family 2 member D
  G protein regulated inducer of neurite outgrowth 1
  G protein subunit alpha 13
  G protein subunit alpha i1
  G protein subunit alpha i3
  G protein subunit alpha q
  G protein subunit gamma 5
  golgi phosphoprotein 3 like
  hexokinase 3
  HRas proto-oncogene, GTPase
  limb development membrane protein 1
  platelet derived growth factor receptor beta
  POTE ankyrin domain family member F
  RAP2A, member of RAS oncogene family
  SRC proto-oncogene, non-receptor tyrosine kinase
  thyroid hormone receptor interactor 6
  tweety family member 3
  WW domain containing E3 ubiquitin protein ligase 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.