F11, coagulation factor XI

F11, coagulation factor XI

• This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq, Jul 2008]

• Gene Synonyms (FXI, PTA, coagulation factor XI, coagualtion factor XI, plasma thromboplastin antecedent,)
• NCBI Gene ID: 2160
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P03951
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

coagulation factor XI interacts with:

• coagulation factor XI
  cysteine rich with EGF like domains 2
  hepatocyte growth factor
  kininogen 1
  NEDD4 binding protein 2 like 2
  proline rich mitotic checkpoint control factor
  serpin family A member 5
  serpin family F member 2
  tissue factor pathway inhibitor 2

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