MS4A2, membrane spanning 4-domains A2

MS4A2, membrane spanning 4-domains A2

• The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of membrane-spanning 4A gene family members. Alternative splicing results in multiple transcript variants encoding distinct proteins. Additional transcript variants have been described but require experimental validation. [provided by RefSeq, Mar 2012]

• Gene Synonyms (APY, ATOPY, FCER1B, FCERI, IGEL, IGER, IGHER, MS4A1, high affinity immunoglobulin epsilon receptor subunit beta, Fc fragment of IgE, high affinity I, receptor for; beta polypeptide, High affinity immunoglobulin epsilon receptor beta-subunit (FcERI) (IgE Fc receptor, beta-subunit) (Fc epsilon receptor I beta-chain), high affinity IgE receptor beta subunit, igE Fc receptor subunit beta, immunoglobulin E receptor, high affinity, beta polypeptide, membrane-spanning 4-domains subfamily A member 2,)
• NCBI Gene ID: 2206
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A0B4J2E9
  UNIPROT ID#>>Q01362
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

membrane spanning 4-domains A2 interacts with:

• growth factor receptor bound protein 2
  heat shock protein 90 alpha family class A member 1
  LYN proto-oncogene, Src family tyrosine kinase
  protein kinase C delta
  protein tyrosine phosphatase non-receptor type 11
  protein tyrosine phosphatase non-receptor type 6
  spleen associated tyrosine kinase
  transmembrane protein 86A
  vav guanine nucleotide exchange factor 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.