GRB2, growth factor receptor bound protein 2

GRB2, growth factor receptor bound protein 2

• The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (growth factor receptor-bound protein 2, HT027, SH2/SH3 adapter GRB2, abundant SRC homology, epidermal growth factor receptor-binding protein GRB2, epididymis secretory sperm binding protein, growth factor receptor-bound protein 3, protein Ash, ASH, EGFRBP-GRB2, Grb3-3, MST084, MSTP084, NCKAP2,)
• NCBI Gene ID: 2885
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P62993
  UNIPROT ID#>>B0LPF3
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

growth factor receptor bound protein 2 interacts with:

• AAR2 splicing factor
  ABI family member 3
  ABI family member 3 binding protein
  abraxas 2, BRISC complex subunit
  ADAM metallopeptidase domain 12
  ADAM metallopeptidase domain 15
  adaptor related protein complex 4 subunit sigma 1
  ADP ribosylation factor like GTPase 6 interacting protein 4
  afadin, adherens junction formation factor
  AHNAK nucleoprotein
  ajuba LIM protein
  ankyrin repeat domain 23
  anterior gradient 2, protein disulphide isomerase family member
  ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
  ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
  ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
  ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
  arginyl-tRNA synthetase 1
  AT-rich interaction domain 5A
  aurora kinase A and ninein interacting protein
  autophagy related 16 like 1
  B cell linker
  BAG cochaperone 3
  BCAR1 scaffold protein, Cas family member
  BRCA1/BRCA2-containing complex subunit 3
  BRISC and BRCA1 A complex member 1
  BRISC and BRCA1 A complex member 2
  c-abl oncogene 1, non-receptor tyrosine kinase
  CASC3 exon junction complex subunit
  caseinolytic mitochondrial matrix peptidase chaperone subunit X
  Cbl proto-oncogene C
  C-C motif chemokine ligand 5
  CCR4-NOT transcription complex subunit 1
  CD164 molecule
  CD2 associated protein
  centrosomal protein 170
  cereblon
  chaperonin containing TCP1 subunit 2
  chaperonin containing TCP1 subunit 3
  chaperonin containing TCP1 subunit 4
  chaperonin containing TCP1 subunit 5
  chaperonin containing TCP1 subunit 7
  chaperonin containing TCP1 subunit 8
  chromosome 1 open reading frame 94
  chromosome 21 open reading frame 58
  chromosome 21 open reading frame 91
  cleavage and polyadenylation specific factor 7
  coiled-coil domain containing 28B
  complement factor H
  cullin 3
  cutA divalent cation tolerance homolog
  cytokine dependent hematopoietic cell linker
  cytoplasmic FMR1 interacting protein 2
  cytoplasmic linker associated protein 2
  DEAD-box helicase 17
  dedicator of cytokinesis 4
  dedicator of cytokinesis 5
  defective in cullin neddylation 1 domain containing 1
  deltex E3 ubiquitin ligase 3
  developmental pluripotency associated 4
  developmentally regulated GTP binding protein 1
  DLG associated protein 1
  DNA damage inducible transcript 4 like
  DnaJ heat shock protein family (Hsp40) member A3
  DnaJ heat shock protein family (Hsp40) member B11
  docking protein 3
  dual specificity phosphatase 13
  dynactin subunit 2
  dynamin 3
  EF-hand domain containing 2
  egl-9 family hypoxia inducible factor 3
  elongation factor Tu GTP binding domain containing 2
  engulfment and cell motility 2
  epidermal growth factor receptor pathway substrate 15 like 1
  epiplakin 1
  ERBB receptor feedback inhibitor 1
  Fas binding factor 1
  fibroblast growth factor receptor 1
  fibroblast growth factor receptor substrate 2
  fibroblast growth factor receptor substrate 3
  formin homology 2 domain containing 1
  FYVE, RhoGEF and PH domain containing 6
  galectin 3 binding protein
  gametogenetin
  gap junction protein alpha 9
  GIT ArfGAP 1
  glutathione S-transferase kappa 1
  G-patch domain and ankyrin repeats 1
  GRB2 associated binding protein 2
  GRB2 associated binding protein 3
  GRB2 associated regulator of MAPK1 subtype 1
  GRB2 associated regulator of MAPK1 subtype 2
  GRB2 related adaptor protein 2
  growth factor receptor bound protein 2
  growth factor receptor bound protein 2-associated protein 2
  growth factor receptor bound protein 7
  H1.0 linker histone
  H3 clustered histone 1
  H4 histone 16
  haptoglobin
  HDGF like 3
  heat shock protein 90 alpha family class A member 1
  heat shock protein 90 alpha family class B member 1
  heat shock protein family A (Hsp70) member 1 like
  heat shock protein family A (Hsp70) member 1B
  heat shock protein family A (Hsp70) member 5
  heat shock protein family A (Hsp70) member 8
  heat shock protein family A (Hsp70) member 9
  heat shock protein family D (Hsp60) member 1
  helicase with zinc finger
  hematopoietic cell-specific Lyn substrate 1
  heparan sulfate proteoglycan 2
  hepatocyte growth factor-regulated tyrosine kinase substrate
  heterogeneous nuclear ribonucleoprotein A2/B1
  heterogeneous nuclear ribonucleoprotein C
  heterogeneous nuclear ribonucleoprotein D
  heterogeneous nuclear ribonucleoprotein K
  heterogeneous nuclear ribonucleoprotein U
  hexosaminidase subunit beta
  histone deacetylase 4
  homeobox and leucine zipper encoding
  homeodomain interacting protein kinase 3
  hormonally up-regulated Neu-associated kinase
  HRas proto-oncogene, GTPase
  huntingtin
  hydroxysteroid 17-beta dehydrogenase 4
  IK cytokine
  IKAROS family zinc finger 3
  IL2 inducible T cell kinase
  inhibitor of CDK, cyclin A1 interacting protein 1
  inosine monophosphate dehydrogenase 2
  inositol polyphosphate phosphatase like 1
  inositol polyphosphate-5-phosphatase D
  insulin like growth factor 2 mRNA binding protein 1
  insulin receptor
  insulin receptor substrate 1
  insulin receptor substrate 2
  insulin receptor substrate 4
  integrin subunit alpha 2b
  integrin subunit alpha 4
  integrin subunit alpha 6
  integrin subunit beta 4
  inter-alpha-trypsin inhibitor heavy chain 4
  interferon regulatory factor 5
  interleukin 2 receptor subunit beta
  interleukin 3 receptor subunit alpha
  interleukin 6 signal transducer
  IQ motif containing GTPase activating protein 1
  itchy E3 ubiquitin protein ligase
  Janus kinase 1
  Janus kinase 2
  karyopherin subunit alpha 2
  keratin 1
  keratin 10
  keratin 14
  keratin 15
  keratin 16
  keratin 17
  keratin 18
  keratin 19
  keratin 2
  keratin 32
  keratin 33B
  keratin 34
  keratin 35
  keratin 36
  keratin 4
  keratin 5
  keratin 6A
  keratin 7
  keratin 73
  keratin 8
  keratin 81
  keratin 82
  keratin 83
  keratin 85
  keratin 86
  keratin 9
  keratinocyte proline rich protein
  KH RNA binding domain containing, signal transduction associated 1
  KH RNA binding domain containing, signal transduction associated 2
  KIAA0408
  KIAA1549 like
  kinase insert domain receptor
  kinesin family member 3A
  kirre like nephrin family adhesion molecule 1
  KIT proto-oncogene, receptor tyrosine kinase
  KRAS proto-oncogene, GTPase
  Lck interacting transmembrane adaptor 1
  leucine rich repeat kinase 1
  leucine zipper tumor suppressor 2
  leukocyte receptor tyrosine kinase
  ligand of numb-protein X 1
  ligand of numb-protein X 2
  LIM domain only 2
  LIM homeobox transcription factor 1 alpha
  linker for activation of T cells
  linker for activation of T cells family member 2
  lymphocyte antigen 6 family member G6F
  lymphocyte cytosolic protein 2
  lymphocyte transmembrane adaptor 1
  macrophage stimulating 1 receptor
  mediator complex subunit 19
  mediator complex subunit 28
  meiotic double-stranded break formation protein 4
  MER proto-oncogene, tyrosine kinase
  MET proto-oncogene, receptor tyrosine kinase
  metastasis associated 1
  metastasis associated 1
  metastasis associated 1 family member 3
  metastasis associated 3
  methyltransferase like 27
  MIA SH3 domain ER export factor 2
  microfibril associated protein 4
  microtubule associated monooxygenase, calponin and LIM domain containing 1
  microtubule associated protein 1A
  microtubule associated protein 2
  microtubule associated protein tau
  minichromosome maintenance complex component 2
  mitochondrially encoded ATP synthase 8
  mitochondrially encoded NADH dehydrogenase 4
  mitogen-activated protein kinase 1
  mitogen-activated protein kinase 12
  mitogen-activated protein kinase 9
  mitogen-activated protein kinase kinase kinase 1
  mitogen-activated protein kinase kinase kinase kinase 1
  mitogen-activated protein kinase kinase kinase kinase 3
  mitogen-activated protein kinase kinase kinase kinase 5
  MLX interacting protein like
  mucin 1, cell surface associated
  multivesicular body subunit 12A
  musashi RNA binding protein 2
  MYG1 exonuclease
  myosin heavy chain 11
  myosin heavy chain 9
  myosin light chain 12A
  myosin light chain 12B
  myosin XVIIIA
  myozenin 1
  NAD kinase
  NCK adaptor protein 1
  NCK associated protein 1
  NCK interacting protein with SH3 domain
  nerve growth factor receptor
  nerve growth factor receptor (TNFR superfamily, member 16)
  neuraminidase 3
  neurofilament heavy
  neurotrophic receptor tyrosine kinase 1
  neutrophil cytosolic factor 1
  NGG1 interacting factor 3 like 1
  nischarin
  NKD inhibitor of WNT signaling pathway 2
  NRAS proto-oncogene, GTPase
  nuclear transcription factor Y subunit beta
  nucleolin
  nucleophosmin 1
  nucleosome assembly protein 1 like 5
  NUT family member 2F
  OCRL inositol polyphosphate-5-phosphatase
  odr-4 GPCR localization factor homolog
  oligodendrocyte transcription factor 1
  OTU deubiquitinase 5
  OTU deubiquitinase with linear linkage specificity like
  p21 (RAC1) activated kinase 1
  p21 (RAC1) activated kinase 2
  p21 (RAC1) activated kinase 4
  par-6 family cell polarity regulator alpha
  paraoxonase 2
  parkin coregulated like
  paxillin
  PBX homeobox interacting protein 1
  peroxisome proliferator activated receptor alpha
  PH domain containing endocytic trafficking adaptor 1
  phosphatase and actin regulator 4
  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
  phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
  phosphodiesterase 4D
  phosphodiesterase 6G
  phosphoinositide-3-kinase adaptor protein 1
  phosphoinositide-3-kinase regulatory subunit 1
  phosphoinositide-3-kinase regulatory subunit 2
  phosphoinositide-3-kinase regulatory subunit 3
  phospholipase C gamma 1
  phosphoprotein membrane anchor with glycosphingolipid microdomains 1
  PIH1 domain containing 1
  platelet derived growth factor receptor alpha
  platelet derived growth factor receptor beta
  pleckstrin homology domain containing A2
  pleckstrin homology domain containing A4
  pleckstrin homology domain containing A7
  pleckstrin homology domain containing S1
  plectin
  plexin B1
  plexin B2
  PNMA family member 5
  prion protein
  programmed cell death 6 interacting protein
  proline rich 22
  proline rich acidic protein 1
  proline rich coiled-coil 2A
  proline rich nuclear receptor coactivator 1
  proline-serine-threonine phosphatase interacting protein 2
  proteasome 26S subunit, ATPase 2
  proteasome 26S subunit, non-ATPase 11
  proteasome 26S subunit, non-ATPase 13
  proteasome 26S subunit, non-ATPase 14
  proteasome activator subunit 1
  proteasome maturation protein
  protein kinase AMP-activated non-catalytic subunit beta 1
  protein kinase cAMP-dependent type I regulatory subunit alpha
  protein phosphatase 1 catalytic subunit alpha
  protein phosphatase 1 catalytic subunit gamma
  protein phosphatase 2 regulatory subunit Balpha
  protein phosphatase 3 catalytic subunit alpha
  protein phosphatase 5 catalytic subunit
  protein tyrosine kinase 2
  protein tyrosine phosphatase non-receptor type 1
  protein tyrosine phosphatase non-receptor type 11
  protein tyrosine phosphatase non-receptor type 12
  protein tyrosine phosphatase non-receptor type 18
  protein tyrosine phosphatase non-receptor type 22
  protein tyrosine phosphatase non-receptor type 23
  protein tyrosine phosphatase non-receptor type 6
  protein tyrosine phosphatase receptor type A
  protein tyrosine phosphatase receptor type C
  protein tyrosine phosphatase receptor type E
  protein tyrosine phosphatase receptor type J
  protocadherin beta 5
  PRR5-ARHGAP8 readthrough
  pseudopodium enriched atypical kinase 1
  Rac family small GTPase 1
  Rac GTPase activating protein 1
  Ral GEF with PH domain and SH3 binding motif 1
  RALBP1 associated Eps domain containing 1
  RALBP1 associated Eps domain containing 2
  Rap associating with DIL domain
  Rap guanine nucleotide exchange factor 1
  ras homolog family member U
  RAS p21 protein activator 1
  RB binding protein 6, ubiquitin ligase
  RB transcriptional corepressor 1
  receptor associated protein of the synapse
  RecQ like helicase 4
  REL proto-oncogene, NF-kB subunit
  replication timing regulatory factor 1
  ret proto-oncogene
  retinol binding protein 4
  Rho GTPase activating protein 12
  Rho GTPase activating protein 17
  Rho GTPase activating protein 32
  Rho GTPase activating protein 35
  Rho GTPase activating protein 9
  Rho guanine nucleotide exchange factor 5
  Rho guanine nucleotide exchange factor 7
  ribosomal protein S19
  ribosomal protein S20
  ribosomal protein S27a
  ribosomal protein S6 kinase A1
  ring finger protein 10
  ring finger protein 208
  RNA binding motif protein 33
  RNA polymerase I and III subunit D
  RNA polymerase II subunit A
  ROS proto-oncogene 1, receptor tyrosine kinase
  RuvB like AAA ATPase 1
  S100 calcium binding protein A8
  S100 calcium binding protein A9
  selectin L
  serine/threonine kinase 32C
  SERPINE1 mRNA binding protein 1
  sex hormone binding globulin
  SH2 domain containing 1A
  SH2 domain containing 4A
  SH2 domain containing 5
  SH2 domain containing adaptor protein B
  SH2B adaptor protein 1
  SH2B adaptor protein 2
  SH2B adaptor protein 3
  SH3 and multiple ankyrin repeat domains 3
  SH3 and PX domains 2A
  SH3 and PX domains 2B
  SH3 domain binding protein 2
  SH3 domain containing 19
  SH3 domain containing kinase binding protein 1
  SH3KBP1 binding protein 1
  SHC adaptor protein 1
  SHC adaptor protein 2
  SHC adaptor protein 3
  SHC adaptor protein 4
  sialic acid binding Ig like lectin 7
  signal regulatory protein alpha
  signaling threshold regulating transmembrane adaptor 1
  SLAIN motif family member 2
  SLX1 homolog A, structure-specific endonuclease subunit
  small nuclear ribonucleoprotein D2 polypeptide
  small nuclear ribonucleoprotein U5 subunit 200
  SMU1 DNA replication regulator and spliceosomal factor
  solute carrier family 1 member 2
  solute carrier family 25 member 13
  sorting nexin 18
  SOS Ras/Rac guanine nucleotide exchange factor 1
  SOS Ras/Rac guanine nucleotide exchange factor 1
  SOS Ras/Rho guanine nucleotide exchange factor 2
  spectrin beta, non-erythrocytic 1
  spermatogenesis associated 2 like
  spleen associated tyrosine kinase
  splicing factor 3a subunit 2
  splicing factor 3b subunit 4
  sprouty RTK signaling antagonist 1
  sprouty RTK signaling antagonist 2
  sprouty RTK signaling antagonist 4
  src homology 2 domain-containing transforming protein C1
  src kinase associated phosphoprotein 1
  src kinase associated phosphoprotein 2
  SRC proto-oncogene, non-receptor tyrosine kinase
  SS18 subunit of BAF chromatin remodeling complex
  STAM binding protein
  StAR related lipid transfer domain containing 10
  STE20 related adaptor beta
  suppressor of cytokine signaling 1
  suppressor of cytokine signaling 4
  suppressor of cytokine signaling 7
  synapsin I
  synaptojanin 1
  synaptojanin 2
  synaptophysin
  synaptotagmin binding cytoplasmic RNA interacting protein
  synemin
  syntrophin alpha 1
  T cell receptor associated transmembrane adaptor 1
  target of myb1 like 1 membrane trafficking protein
  TBC1 domain family member 3B
  TBC1 domain family member 3G
  t-complex 1
  tec protein tyrosine kinase
  TEK receptor tyrosine kinase
  tensin 2
  tetraspanin 2
  TGF-beta activated kinase 1 (MAP3K7) binding protein 1
  thymocyte selection associated
  TNF receptor superfamily member 1A
  trafficking from ER to golgi regulator
  transcription elongation factor A like 8
  transcription elongation regulator 1
  transferrin
  transmembrane protein 128
  tribbles pseudokinase 3
  tripartite motif containing 25
  tripartite motif containing 27
  TSC complex subunit 2
  TUB bipartite transcription factor
  tubulin alpha 1c
  tubulin alpha 4b
  tubulin beta 4B class IVb
  tubulin beta class I
  tumor protein p53 binding protein 2
  tumor protein p63
  tumor susceptibility 101
  tweety family member 2
  TXK tyrosine kinase
  TYRO3 protein tyrosine kinase
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  tyrosine kinase non receptor 2
  ubiquinol-cytochrome c reductase complex assembly factor 2
  ubiquitin A-52 residue ribosomal protein fusion product 1
  ubiquitin associated and SH3 domain containing B
  ubiquitin C
  ubiquitin like modifier activating enzyme 1
  ubiquitin protein ligase E3 component n-recognin 4
  ubiquitin specific peptidase 12
  ubiquitin specific peptidase 53
  ubiquitin specific peptidase 8
  USP6 N-terminal like
  valosin containing protein
  vascular cell adhesion molecule 1
  vasodilator stimulated phosphoprotein
  vav 1 oncogene
  vav guanine nucleotide exchange factor 1
  vav guanine nucleotide exchange factor 2
  vav guanine nucleotide exchange factor 3
  vimentin
  VPS28 subunit of ESCRT-I
  VPS37B subunit of ESCRT-I
  VPS37C subunit of ESCRT-I
  WAS/WASL interacting protein family member 1
  WAS/WASL interacting protein family member 2
  WAS/WASL interacting protein family member 3
  WASP actin nucleation promoting factor
  WASP family member 1
  WASP family member 2
  WASP like actin nucleation promoting factor
  WD repeat and FYVE domain containing 3
  WD repeat domain 1
  WD repeat domain 44
  WD repeat domain 6
  WD repeat domain 77
  WW domain binding protein 11
  WW domain containing E3 ubiquitin protein ligase 2
  YLP motif containing 1
  zeta chain of T cell receptor associated protein kinase 70
  zinc finger and BTB domain containing 12
  zinc finger and BTB domain containing 7B
  zinc finger matrin-type 1
  zinc finger MYM-type containing 6
  zinc finger protein 341
  zinc finger protein 474
  zinc finger protein 620

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.