GJA1, gap junction protein alpha 1

GJA1, gap junction protein alpha 1

• This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia, autosomal recessive craniometaphyseal dysplasia and heart malformations. [provided by RefSeq, May 2014]

• Gene Synonyms (gap junction alpha-1 protein, connexin-43, gap junction 43 kDa heart protein, gap junction protein, alpha 1, 43kDa, AVSD3, CMDR, CX43, EKVP, EKVP3, GJAL, HLHS1, HSS, ODDD, PPKCA,)
• NCBI Gene ID: 2697
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P17302
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

gap junction protein alpha 1 interacts with:

• 5-hydroxytryptamine receptor 3A
  5-hydroxytryptamine receptor 3C
  5'-nucleotidase ecto
  adhesion G protein-coupled receptor G5
  autophagy related 14
  autophagy related 16 like 1
  autophagy related 5
  beclin 1
  Bet1 golgi vesicular membrane trafficking protein
  beta-1,4-glucuronyltransferase 1
  cAMP responsive element binding protein 3
  cellular communication network factor 3
  consortin, connexin sorting protein
  cyclic GMP-AMP synthase
  family with sequence similarity 189 member A2
  G protein-coupled receptor 21
  G protein-coupled receptor 52
  gap junction protein alpha 1
  gap junction protein alpha 3
  gap junction protein alpha 5
  hepatocyte growth factor-regulated tyrosine kinase substrate
  KRAS proto-oncogene, GTPase
  limb development membrane protein 1 like
  lysosomal associated membrane protein 1
  mitogen-activated protein kinase 1
  mitogen-activated protein kinase 3
  mitogen-activated protein kinase 7
  NADH:ubiquinone oxidoreductase subunit A7
  NEDD4 E3 ubiquitin protein ligase
  ninjurin 2
  NRAS proto-oncogene, GTPase
  phosphatidylinositol 3-kinase catalytic subunit type 3
  phosphoinositide-3-kinase regulatory subunit 4
  phospholipid phosphatase 4
  potassium two pore domain channel subfamily K member 16
  proteasome 26S subunit, non-ATPase 2
  proteasome 26S subunit, non-ATPase 4
  protein kinase C alpha
  protein kinase C beta
  protein kinase C epsilon
  protein kinase C gamma
  pyrimidinergic receptor P2Y6
  S100 calcium binding protein A1
  small G protein signaling modulator 3
  solute carrier family 15 member 3
  solute carrier family 39 member 12
  solute carrier family 39 member 4
  SRC proto-oncogene, non-receptor tyrosine kinase
  STAM binding protein
  syntaxin binding protein 1
  syntaxin binding protein 2
  tetraspanin 17
  tight junction protein 1
  trans-golgi network protein 2
  transmembrane protein 128
  transmembrane protein 86B
  transmembrane serine protease 3
  tumor susceptibility 101
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  ubiquilin 4
  ubiquitin conjugating enzyme E2 A
  ubiquitin specific peptidase 8
  uroplakin 1A
  zinc activated ion channel

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.