GSTA1, glutathione S-transferase alpha 1

GSTA1, glutathione S-transferase alpha 1

• This gene encodes a member of a family of enzymes that function to add glutathione to target electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress. This action is an important step in detoxification of these compounds. This subfamily of enzymes has a particular role in protecting cells from reactive oxygen species and the products of peroxidation. Polymorphisms in this gene influence the ability of individuals to metabolize different drugs. This gene is located in a cluster of similar genes and pseudogenes on chromosome 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

• Gene Synonyms (glutathione S-transferase A1, 13-hydroperoxyoctadecadienoate peroxidase, GST HA subunit 1, GST class-alpha member 1, S-(hydroxyalkyl)glutathione lyase A1, androst-5-ene-3,17-dione isomerase, glutathione S-alkyltransferase A1, glutathione S-aryltransferase A1, glutathione S-transferase 2, glutathione S-transferase Ha subunit 1, testicular tissue protein Li 80, GST-epsilon, GST2, GSTA1-1, GTH1,)
• NCBI Gene ID: 2938
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P08263
  UNIPROT ID#>>B7Z1F9
  UNIPROT ID#>>A0A140VJK4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

glutathione S-transferase alpha 1 interacts with:

• BAG cochaperone 3
  gamma-glutamyltransferase light chain 1
  GAR1 ribonucleoprotein
  glutathione S-transferase alpha 1
  glutathione S-transferase alpha 2
  glutathione S-transferase alpha 3
  glutathione S-transferase alpha 4
  LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated
  protein phosphatase 2 catalytic subunit beta
  RPA interacting protein
  spindle apparatus coiled-coil protein 1
  ST3 beta-galactoside alpha-2,3-sialyltransferase 1
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
  zinc finger and BTB domain containing 21

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.