GUCY1B1, guanylate cyclase 1 soluble subunit beta 1

GUCY1B1, guanylate cyclase 1 soluble subunit beta 1

• This gene encodes the beta subunit of the soluble guanylate cyclase (sGC), which catalyzes the conversion of GTP (guanosine triphosphate) to cGMP (cyclic guanosine monophosphate). The encoded protein contains an HNOX domain, which serves as a receptor for ligands such as nitric oxide, oxygen and nitrovasodilator drugs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

• Gene Synonyms (guanylate cyclase soluble subunit beta-1, GCS-beta-1, GCS-beta-3, guanylate cyclase 1, soluble, beta 3, guanylate cyclase soluble subunit beta-3, soluble guanylate cyclase small subunit, GC-S-beta-1, GC-SB3, GUC1B3, GUCB3, GUCSB3, GUCY1B3,)
• NCBI Gene ID: 2983
• Species: Homo sapiens (Human)
• UNIPROT ID#>>D6RC99
  UNIPROT ID#>>Q02153
  UNIPROT ID#>>B7Z6G8
  UNIPROT ID#>>B7Z685
  UNIPROT ID#>>B7Z9H9
  UNIPROT ID#>>E9PCN2
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

guanylate cyclase 1 soluble subunit beta 1 interacts with:

• ankyrin repeat and MYND domain containing 2
  ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
  heat shock protein 90 alpha family class A member 1
  lin-7 homolog A, crumbs cell polarity complex component
  matrix remodeling associated 7
  mitochondrial E3 ubiquitin protein ligase 1
  mitochondrial fission regulator 2
  MYC binding protein 2
  NADPH oxidase 5
  nitric oxide synthase 3
  STIP1 homology and U-box containing protein 1
  TNFAIP3 interacting protein 2
  uveal autoantigen with coiled-coil domains and ankyrin repeats

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