NOS3, nitric oxide synthase 3

NOS3, nitric oxide synthase 3

• Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016]

• Gene Synonyms (ECNOS, eNOS, nitric oxide synthase, endothelial, EC-NOS, NOS type III, NOSIII, cNOS, constitutive NOS, endothelial NOS, nitric oxide synthase 3 (endothelial cell), nitric oxide synthase 3 transcript variant eNOS-delta20, nitric oxide synthase 3 transcript variant eNOS-delta20-21, nitric oxide synthase 3 transcript variant eNOS-delta21,)
• NCBI Gene ID: 4846
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A0A0MTA6
  UNIPROT ID#>>A0S0A6
  UNIPROT ID#>>P29474
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

nitric oxide synthase 3 interacts with:

• cell division cycle 37, HSP90 cochaperone
  centrosomal protein 55
  EGF containing fibulin extracellular matrix protein 2
  exocyst complex component 6
  exosome component 1
  fission, mitochondrial 1
  histone deacetylase 3
  HtrA serine peptidase 1
  IKAROS family zinc finger 3
  inner membrane mitochondrial protein
  KN motif and ankyrin repeat domains 2
  microtubule associated serine/threonine kinase 1
  myosin phosphatase Rho interacting protein
  nitric oxide synthase 3
  nitric oxide synthase interacting protein
  nitric oxide synthase trafficking
  PAX interacting protein 1
  phosphatidylinositol 4-kinase type 2 alpha
  presenilin 1
  presenilin 2
  protein phosphatase 2 phosphatase activator
  protein phosphatase 2 regulatory subunit B'alpha
  ring finger protein 31
  ring finger protein 32
  sirtuin 1
  Sp1 transcription factor
  ST13 Hsp70 interacting protein
  thioredoxin domain containing 11
  trans-2,3-enoyl-CoA reductase
  uridine monophosphate synthetase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.