SERPIND1, serpin family D member 1

SERPIND1, serpin family D member 1

• This gene belongs to the serpin gene superfamily. Serpins play roles in many processes including inflammation, blood clotting, and cancer metastasis. Members of this family have highly conserved secondary structures with a reactive center loop that interacts with the protease active site to inhibit protease activity. This gene encodes a plasma serine protease that functions as a thrombin and chymotrypsin inhibitor. The protein is activated by heparin, dermatan sulfate, and glycosaminoglycans. Allelic variations in this gene are associated with heparin cofactor II deficiency. [provided by RefSeq, Jul 2015]

• Gene Synonyms (heparin cofactor 2, leuserpin 2, protease inhibitor leuserpin-2, serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1, serpin D1, serpin peptidase inhibitor, clade D (heparin cofactor), member 1, D22S673, HC2, HCF2, HCII, HLS2, LS2, THPH10,)
• NCBI Gene ID: 3053
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P05546
  UNIPROT ID#>>Q8IVC0
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

serpin family D member 1 interacts with:

• DDB1 and CUL4 associated factor 4
  serpin family D member 1
  vesicle amine transport 1 like

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.