IAPP, islet amyloid polypeptide

IAPP, islet amyloid polypeptide

• This gene encodes a member of the calcitonin family of peptide hormones. This hormone is released from pancreatic beta cells following food intake to regulate blood glucose levels and act as a satiation signal. Human patients with type 1 and advanced type 2 diabetes exhibit reduced levels of the encoded hormone in blood and pancreas. This protein also exhibits a bactericidal, antimicrobial activity. [provided by RefSeq, Jul 2016]

• Gene Synonyms (islet amyloid polypeptide, Islet amyloid polypeptide (diabetes-associated peptide; amylin), amylin, diabetes-associated peptide, insulinoma amyloid peptide, DAP, IAP,)
• NCBI Gene ID: 3375
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024RAU1
  UNIPROT ID#>>P10997
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

islet amyloid polypeptide interacts with:

• collagen type XXV alpha 1 chain
  pancreatic and duodenal homeobox 1
  prolyl 4-hydroxylase subunit beta
  proprotein convertase subtilisin/kexin type 1
  proprotein convertase subtilisin/kexin type 2
  receptor activity modifying protein 1
  receptor activity modifying protein 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.