COL25A1, collagen type XXV alpha 1 chain

COL25A1, collagen type XXV alpha 1 chain

• This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

• Gene Synonyms (collagen alpha-1(XXV) chain, alzheimer disease amyloid-associated protein, collagen-like Alzheimer amyloid plaque component, collagenous Alzheimer amyloid plaque component, AMY, CFEOM5, CLAC, CLAC-P, CLACP,)
• NCBI Gene ID: 84570
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9BXS0
  UNIPROT ID#>>A8MWQ5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

collagen type XXV alpha 1 chain interacts with:

• collagen type XXV alpha 1 chain

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