ISL1, ISL LIM homeobox 1

ISL1, ISL LIM homeobox 1

• This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young. [provided by RefSeq, Jul 2008]

• Gene Synonyms (ISLET1, Isl-1, insulin gene enhancer protein ISL-1, ISL1 transcription factor, LIM/homeodomain, islet-1,)
• NCBI Gene ID: 3670
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P61371
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ISL LIM homeobox 1 interacts with:

• ariadne RBR E3 ubiquitin protein ligase 1
  COP9 signalosome subunit 5
  ISL LIM homeobox 1
  ISL LIM homeobox 2
  LIM domain binding 1
  LIM domain binding 2
  LIM domain only 2
  LIM homeobox 1
  LIM homeobox 3
  LIM homeobox 4
  LIM homeobox transcription factor 1 alpha
  lysine demethylase 1A
  MAF bZIP transcription factor A
  MAF bZIP transcription factor B
  nuclear factor of activated T cells 1
  nuclear receptor subfamily 2 group F member 1
  peroxisomal trans-2-enoyl-CoA reductase
  phospholipase C gamma 2
  RELA proto-oncogene, NF-kB subunit
  ring finger protein 20
  ring finger protein 40
  ring finger protein, LIM domain interacting
  single stranded DNA binding protein 2
  single stranded DNA binding protein 3
  single stranded DNA binding protein 4
  SMAD family member 3
  zinc finger protein 511

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.