KCNJ3, potassium inwardly rectifying channel subfamily J member 3

KCNJ3, potassium inwardly rectifying channel subfamily J member 3

• Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and plays an important role in regulating heartbeat. It associates with three other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex that also couples to neurotransmitter receptors in the brain and whereby channel activation can inhibit action potential firing by hyperpolarizing the plasma membrane. These multimeric G-protein-gated inwardly-rectifying potassium (GIRK) channels may play a role in the pathophysiology of epilepsy, addiction, Down's syndrome, ataxia, and Parkinson's disease. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, May 2012]

• Gene Synonyms (GIRK1, KGA, KIR3.1, G protein-activated inward rectifier potassium channel 1, GIRK-1, inward rectifier K(+) channel Kir3.1, inward rectifier K+ channel KIR3.1, potassium channel, inwardly rectifying subfamily J member 3, potassium inwardly-rectifying channel subfamily J member 3 splice variant 1e, potassium voltage-gated channel subfamily J member 3,)
• NCBI Gene ID: 3760
• Species: Homo sapiens (Human)
• UNIPROT ID#>>D2XBF0
  UNIPROT ID#>>P48549
  UNIPROT ID#>>D2X9V0
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

potassium inwardly rectifying channel subfamily J member 3 interacts with:

• potassium inwardly rectifying channel subfamily J member 3
  potassium inwardly rectifying channel subfamily J member 5
  potassium inwardly rectifying channel subfamily J member 6
  potassium inwardly rectifying channel subfamily J member 9

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