NBR1, NBR1 autophagy cargo receptor

NBR1, NBR1 autophagy cargo receptor

• The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]

• Gene Synonyms (1A1-3B, IAI3B, M17S2, MIG19, next to BRCA1 gene 1 protein, B-box protein, cell migration-inducing gene 19 protein, membrane component, chromosome 17, surface marker 2 (ovarian carcinoma antigen CA125), migration-inducing protein 19, neighbor of BRCA1 gene 1,)
• NCBI Gene ID: 4077
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B7Z5R6
  UNIPROT ID#>>A0A024R1V3
  UNIPROT ID#>>Q14596
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

NBR1 autophagy cargo receptor interacts with:

• ataxin 1 like
  axin 1
  calcium and integrin binding 1
  centrosomal protein 135
  centrosomal protein 55
  coronin 6
  DDB1 and CUL4 associated factor 15
  double PHD fingers 2
  elongation factor Tu GTP binding domain containing 2
  fasciculation and elongation protein zeta 1
  G2 and S-phase expressed 1
  GABA type A receptor associated protein like 1
  GABA type A receptor associated protein like 2
  GABA type A receptor-associated protein
  intersectin 2
  kelch like ECH associated protein 1
  limb development membrane protein 1 like
  LY6/PLAUR domain containing 4
  methionyl aminopeptidase 1
  microtubule associated protein 1 light chain 3 alpha
  microtubule associated protein 1 light chain 3 beta
  microtubule associated protein 1 light chain 3 gamma
  microtubule-associated protein 1 light chain 3 beta
  mitochondrial ribosomal protein L41
  mitogen-activated protein kinase kinase 4
  mitogen-activated protein kinase kinase kinase 3
  NBR1 autophagy cargo receptor
  secretagogin, EF-hand calcium binding protein
  sequestosome 1
  sequestosome 1
  signal peptide peptidase like 2B
  slingshot protein phosphatase 3
  sprouty related EVH1 domain containing 2
  sprouty-related EVH1 domain containing 2
  synaptotagmin 4
  titin
  TNFAIP3 interacting protein 1
  toll interacting protein
  tyrosine kinase non receptor 2
  ubiquitin C
  ubiquitin conjugating enzyme E2 D2
  ubiquitin conjugating enzyme E2 D3
  ubiquitin specific peptidase 8
  VAMP associated protein B and C
  vesicle trafficking 1
  vir like m6A methyltransferase associated

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.