MAP4, microtubule associated protein 4

MAP4, microtubule associated protein 4

• The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

• Gene Synonyms (microtubule-associated protein 4, MAP-4,)
• NCBI Gene ID: 4134
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P27816
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

microtubule associated protein 4 interacts with:

• AAR2 splicing factor
  anoctamin 7
  ATP binding cassette subfamily E member 1
  autophagy related 16 like 1
  BAG cochaperone 3
  bromodomain containing 7
  BTB and CNC homology 1, basic leucine zipper transcription factor 1
  coiled-coil domain containing 8
  component of oligomeric golgi complex 7
  cullin 4A
  cytoplasmic linker associated protein 1
  DDB1 and CUL4 associated factor 15
  elongation factor Tu GTP binding domain containing 2
  erbb2 interacting protein
  FYVE and coiled-coil domain autophagy adaptor 1
  G3BP stress granule assembly factor 1
  heterogeneous nuclear ribonucleoprotein R
  HEXIM P-TEFb complex subunit 1
  integrin alpha FG-GAP repeat containing 1
  ISG15 ubiquitin like modifier
  leucine rich repeat containing G protein-coupled receptor 4
  leucine rich repeat kinase 2
  LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated
  LSM8 homolog, U6 small nuclear RNA associated
  metastasis associated 1 family member 2
  microtubule affinity regulating kinase 1
  microtubule affinity regulating kinase 4
  MYC proto-oncogene, bHLH transcription factor
  neurotrophic receptor tyrosine kinase 1
  NOP58 ribonucleoprotein
  nuclear receptor subfamily 1 group I member 3
  nuclear receptor subfamily 2 group C member 2
  OTU deubiquitinase, ubiquitin aldehyde binding 1
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  pre-mRNA processing factor 8
  programmed cell death 6
  prohibitin
  protection of telomeres 1
  protein phosphatase 1 catalytic subunit alpha
  protein phosphatase 4 regulatory subunit 1
  replication protein A1
  replication protein A2
  replication protein A3
  retinoid X receptor beta
  retinoid X receptor gamma
  rhomboid domain containing 1
  ribosomal protein S20
  RNA polymerase II subunit A
  RNA polymerase II subunit C
  SERPINE1 mRNA binding protein 1
  SH3 domain containing kinase binding protein 1
  sirtuin 7
  spermatid perinuclear RNA binding protein
  SRSF protein kinase 2
  STE20 like kinase
  syntrophin alpha 1
  TAR DNA binding protein
  telomeric repeat binding factor 1
  TRAF3 interacting protein 1
  tubulin beta class I
  ubiquitin C
  ubiquitin conjugating enzyme E2 M
  ubiquitin specific peptidase 14
  ubiquitin specific peptidase 21
  vir like m6A methyltransferase associated
  WD repeat and HMG-box DNA binding protein 1
  WW domain containing E3 ubiquitin protein ligase 2
  Yes1 associated transcriptional regulator

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.