POLR2A, RNA polymerase II subunit A

POLR2A, RNA polymerase II subunit A

• This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. [provided by RefSeq, Jul 2008]

• Gene Synonyms (DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II largest subunit, RNA polymerase II 220 kd subunit, DNA-directed RNA polymerase II subunit A, DNA-directed RNA polymerase III largest subunit, RNA polymerase II subunit B1, RNA-directed RNA polymerase II subunit RPB1, polymerase (RNA) II (DNA directed) polypeptide A, 220kDa, polymerase (RNA) II subunit A, NEDHIB, POLR2, POLRA, RPB1, RPBh1, RPO2, RPOL2, RpIILS, hRPB220, hsRPB1,)
• NCBI Gene ID: 5430
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P24928
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

RNA polymerase II subunit A interacts with:

• 5'-3' exoribonuclease 2
  activating transcription factor 7 interacting protein
  Aly/REF export factor
  ankyrin repeat and SOCS box containing 6
  anterior gradient 2, protein disulphide isomerase family member
  anti-silencing function 1A histone chaperone
  argonaute RISC catalytic component 2
  argonaute RISC component 1
  autophagy related 16 like 1
  base methyltransferase of 25S rRNA 2 homolog
  bromodomain adjacent to zinc finger domain 1B
  BTB and CNC homology 1, basic leucine zipper transcription factor 1
  calcineurin binding protein 1
  calcium binding and coiled-coil domain 1
  calcium binding and coiled-coil domain 2
  CCCTC-binding factor
  CCR4-NOT transcription complex subunit 1
  cell division cycle 14A
  cell division cycle 73
  centrosomal protein 128
  chromobox 3
  cleavage and polyadenylation specific factor 1
  cleavage and polyadenylation specific factor 2
  cleavage and polyadenylation specific factor 3
  CLP1, cleavage and polyadenylation factor I subunit
  coiled-coil domain containing 8
  collagen like tail subunit of asymmetric acetylcholinesterase
  copine 2
  CTD phosphatase subunit 1
  CTD small phosphatase 1
  CTD small phosphatase 2
  CTR9 homolog, Paf1/RNA polymerase II complex component
  cullin 1
  cullin 2
  cullin 3
  cullin 5
  cullin 7
  cullin associated and neddylation dissociated 1
  cyclin dependent kinase 12
  cyclin K
  cyclin L2
  DEAD-box helicase 17
  defective in cullin neddylation 1 domain containing 1
  dynactin subunit 2
  E1A binding protein p300
  egl-9 family hypoxia inducible factor 1
  egl-9 family hypoxia inducible factor 2
  egl-9 family hypoxia inducible factor 3
  EH domain binding protein 1 like 1
  elongation factor for RNA polymerase II
  elongation factor Tu GTP binding domain containing 2
  elongator acetyltransferase complex subunit 3
  elongin A
  embryonic ectoderm development
  estrogen receptor binding site associated antigen 9
  eukaryotic elongation factor, selenocysteine-tRNA specific
  eukaryotic translation initiation factor 3, subunit A
  exportin 1
  G protein-coupled receptor 156
  general transcription factor IIB
  general transcription factor IIIC subunit 3
  GPN-loop GTPase 1
  GPN-loop GTPase 3
  H2B clustered histone 21
  H4 clustered histone 1
  heterogeneous nuclear ribonucleoprotein R
  histone cell cycle regulator
  histone deacetylase 11
  HIV-1 Tat specific factor 1
  huntingtin associated protein 1
  influenza virus NS1A binding protein
  INO80 complex subunit B
  integrator complex subunit 1
  integrator complex subunit 10
  integrator complex subunit 11
  integrator complex subunit 14
  integrator complex subunit 3
  integrator complex subunit 5
  integrator complex subunit 6
  interacts with SUPT6H, CTD assembly factor 1
  intraflagellar transport associated protein
  itchy E3 ubiquitin protein ligase
  LEO1 homolog, Paf1/RNA polymerase II complex component
  leucine rich repeat containing G protein-coupled receptor 4
  lysine acetyltransferase 2B
  lysine methyltransferase 2D
  mediator complex subunit 1
  mediator complex subunit 10
  mediator complex subunit 18
  mediator complex subunit 19
  mediator complex subunit 20
  mediator complex subunit 21
  mediator complex subunit 22
  mediator complex subunit 23
  mediator complex subunit 26
  mediator complex subunit 28
  mediator complex subunit 29
  mediator complex subunit 30
  mediator complex subunit 4
  mediator complex subunit 9
  mediator of DNA damage checkpoint 1
  metastasis associated 1 family member 2
  methyl-CpG binding domain protein 2
  mitogen-activated protein kinase 6
  negative elongation factor complex member A
  negative elongation factor complex member B
  negative elongation factor complex member E
  neural precursor cell expressed, developmentally down-regulated 4
  neuralized E3 ubiquitin protein ligase 4
  NMDA receptor synaptonuclear signaling and neuronal migration factor
  nuclear receptor binding SET domain protein 1
  nuclear receptor interacting protein 1
  nuclear receptor subfamily 0 group B member 2
  nuclear RNA export factor 1
  nucleic acid binding protein 1
  obscurin like cytoskeletal adaptor 1
  OTU deubiquitinase 5
  PAF1 homolog, Paf1/RNA polymerase II complex component
  PDX1 C-terminal inhibiting factor 1
  peptidylprolyl isomerase G
  PHD finger protein 8
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  polyglutamine binding protein 1
  polynucleotide kinase 3'-phosphatase
  prefoldin 2
  pre-mRNA processing factor 19
  proteasome 20S subunit alpha 5
  proteasome 20S subunit alpha 6
  proteasome 20S subunit beta 9
  protein arginine methyltransferase 5
  protein phosphatase 1 catalytic subunit alpha
  protein phosphatase 1 catalytic subunit gamma
  protein phosphatase 4 regulatory subunit 1
  protein phosphatase 4 regulatory subunit 3A
  protein tyrosine kinase 6
  pyrin and HIN domain family member 1
  QKI, KH domain containing RNA binding
  RAD52 homolog, DNA repair protein
  ralA binding protein 1
  RecQ like helicase 4
  RecQ like helicase 5
  regulation of nuclear pre-mRNA domain containing 1B
  regulation of nuclear pre-mRNA domain containing 1B
  RELA proto-oncogene, NF-kB subunit
  replication protein A1
  retinoid X receptor alpha
  ribosomal protein S20
  ring finger protein 123
  ring-box 1
  RNA guanylyltransferase and 5'-phosphatase
  RNA polymerase II associated protein 2
  RNA polymerase II associated protein 3
  RNA polymerase II subunit A
  RNA polymerase II subunit B
  RNA polymerase II subunit C
  RNA polymerase II subunit D
  RNA polymerase II subunit G
  RNA polymerase II subunit I
  RNA polymerase II subunit J
  RNA polymerase II subunit M
  RNA polymerase II, I and III subunit E
  RNA polymerase II, I and III subunit F
  RNA polymerase II, I and III subunit H
  RNA polymerase II, I and III subunit K
  RNA polymerase II, I and III subunit L
  RNA polymerase III subunit A
  RNA polymerase III subunit B
  RuvB like AAA ATPase 2
  RuvB-like protein 1
  RuvB-like protein 2
  scaffold attachment factor B
  senataxin
  serine and arginine rich splicing factor 2
  serrate, RNA effector molecule
  SET and MYND domain containing 3
  SET domain containing 1A, histone lysine methyltransferase
  SET domain containing 1B, histone lysine methyltransferase
  SET domain containing 2, histone lysine methyltransferase
  sirtuin 7
  SMAD specific E3 ubiquitin protein ligase 1
  small nuclear ribonucleoprotein D1 polypeptide
  small nuclear ribonucleoprotein D2 polypeptide
  small nuclear ribonucleoprotein D3 polypeptide
  small nuclear ribonucleoprotein polypeptide A
  small nuclear ribonucleoprotein polypeptide C
  small nuclear ribonucleoprotein polypeptides B and B1
  small nuclear ribonucleoprotein U1 subunit 70
  S-phase kinase associated protein 2
  SPT4 homolog, DSIF elongation factor subunit
  SPT5 homolog, DSIF elongation factor subunit
  SPT6 homolog, histone chaperone and transcription elongation factor
  SPT6, histone chaperone and transcription elongation factor
  SRC proto-oncogene, non-receptor tyrosine kinase
  SSU72 homolog, RNA polymerase II CTD phosphatase
  staphylococcal nuclease and tudor domain containing 1
  sterol regulatory element binding transcription factor 1
  STN1 subunit of CST complex
  structural maintenance of chromosomes 1A
  structural maintenance of chromosomes 3
  structure specific recognition protein 1
  SUB1 regulator of transcription
  superoxide dismutase 1
  suppressor of cancer cell invasion
  suppressor of cytokine signaling 2
  suppressor of cytokine signaling 6
  survival of motor neuron 1, telomeric
  survival of motor neuron 2, centromeric
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
  synapse defective Rho GTPase homolog 1
  TATA-box binding protein
  TATA-box binding protein associated factor 10
  TATA-box binding protein associated factor 11
  TATA-box binding protein associated factor 15
  TATA-box binding protein associated factor 4
  tectonic family member 3
  thyroid hormone receptor interactor 4
  TNFAIP3 interacting protein 2
  trafficking kinesin protein 1
  transcription elongation factor A1
  transcription elongation regulator 1
  transcriptional adaptor 2A
  transforming growth factor beta 1
  translocation associated membrane protein 2
  trefoil factor 1
  tripartite motif containing 28
  TTK protein kinase
  tudor domain containing 3
  tumor protein p53
  U2 small nuclear RNA auxiliary factor 2
  ubinuclein 1
  ubiquitin conjugating enzyme E2 L3
  ubiquitin protein ligase E3B
  ubiquitin specific peptidase like 1
  ubiquitously expressed prefoldin like chaperone
  unk zinc finger
  UPF1 RNA helicase and ATPase
  URI1 prefoldin like chaperone
  valosin containing protein
  vir like m6A methyltransferase associated
  vitamin D receptor
  von Hippel-Lindau tumor suppressor
  WD repeat and HMG-box DNA binding protein 1
  WD repeat domain 82
  WD repeat domain 92
  WW domain containing adaptor with coiled-coil
  WW domain containing E3 ubiquitin protein ligase 2
  WW domain containing oxidoreductase
  X-box binding protein 1
  XPA binding protein 2
  XPA, DNA damage recognition and repair factor
  X-ray repair cross complementing 5
  Yes1 associated transcriptional regulator
  yes-associated protein 1
  zinc finger CCCH-type containing 13
  zinc finger protein 131
  zinc finger protein 326
  zinc finger protein 74

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.