MNAT1, MNAT1 component of CDK activating kinase

MNAT1, MNAT1 component of CDK activating kinase

• The protein encoded by this gene, along with cyclin H and CDK7, forms the CDK-activating kinase (CAK) enzymatic complex. This complex activates several cyclin-associated kinases and can also associate with TFIIH to activate transcription by RNA polymerase II. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

• Gene Synonyms (CAP35, MAT1, RNF66, TFB3, CDK-activating kinase assembly factor MAT1, CDK7/cyclin-H assembly factor, MNAT CDK-activating kinase assembly factor 1, MNAT1, CDK activating kinase assembly factor, RING finger protein 66, RING finger protein MAT1, cyclin G1 interacting protein, menage a trois 1 (CAK assembly factor), menage a trois homolog 1, cyclin H assembly factor, menage a trois-like protein 1 cyclin H assembly factor,)
• NCBI Gene ID: 4331
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R688
  UNIPROT ID#>>A0A024R669
  UNIPROT ID#>>P51948
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

MNAT1 component of CDK activating kinase interacts with:

• brain expressed X-linked 3
  ciliogenesis associated kinase 1
  COP9 signalosome subunit 6
  DNA methyltransferase 1 associated protein 1
  egl-9 family hypoxia inducible factor 3
  forkhead box P1
  general transcription factor IIH subunit 5
  H2B clustered histone 8
  HPS6 biogenesis of lysosomal organelles complex 2 subunit 3
  ligand dependent nuclear receptor interacting factor 1
  MAGE family member C2
  MAGE family member E2
  makorin ring finger protein 3
  metastasis associated 1
  MYC proto-oncogene, bHLH transcription factor
  NK3 homeobox 1
  PDX1 C-terminal inhibiting factor 1
  POU class 2 homeobox 1
  POU class 2 homeobox 2
  POU class 5 homeobox 1
  RB transcriptional corepressor 1
  replication protein A1
  replication protein A2
  replication protein A3
  ribosomal protein L35
  ring finger protein 32
  ring finger protein 41
  ring finger protein 7
  RNA binding motif protein 48
  RNA polymerase II subunit A
  sirtuin 6
  Sp1 transcription factor
  SPT5 homolog, DSIF elongation factor subunit
  SWI5 dependent homologous recombination repair protein 1
  tripartite motif containing 14
  tripartite motif containing 17
  tripartite motif containing 2
  tripartite motif containing 21
  tripartite motif containing 26
  tripartite motif containing 31
  tripartite motif containing 34
  tripartite motif containing 39
  tripartite motif containing 5
  tripartite motif containing 9
  tripartite motif family like 1
  tumor protein p53
  tumor protein p53 binding protein 1
  ubiquitin specific peptidase 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.