NCF2, neutrophil cytosolic factor 2

NCF2, neutrophil cytosolic factor 2

• This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2010]

• Gene Synonyms (NCF-2, NOXA2, P67-PHOX, P67PHOX, neutrophil cytosol factor 2, 67 kDa neutrophil oxidase factor, NADPH oxidase activator 2, chronic granulomatous disease, autosomal 2, neutrophil NADPH oxidase factor 2, neutrophil cytosolic factor 2 (65kD, chronic granulomatous disease, autosomal 2),)
• NCBI Gene ID: 4688
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A0S2Z457
  UNIPROT ID#>>P19878
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

neutrophil cytosolic factor 2 interacts with:

• calmodulin regulated spectrin associated protein family member 3
  kinesin associated protein 3
  neutrophil cytosolic factor 1
  neutrophil cytosolic factor 4
  peroxiredoxin 6
  phospholipase A2 group IVA
  protein kinase, DNA-activated, catalytic subunit
  Rac family small GTPase 1
  Rac family small GTPase 2
  S100 calcium binding protein A8
  S100 calcium binding protein A9
  synaptotagmin like 1
  TAR DNA binding protein
  TBC1 domain family member 4
  TNF receptor associated factor 4
  ubiquitin specific peptidase 47

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.