DDR2, discoidin domain receptor tyrosine kinase 2

DDR2, discoidin domain receptor tyrosine kinase 2

• This gene encodes a member of the discoidin domain receptor subclass of the receptor tyrosine kinase (RTKs) protein family. RTKs play a key role in the communication of cells with their microenvironment. The encoded protein is a collagen-induced receptor that activates signal transduction pathways involved in cell adhesion, proliferation, and extracellular matrix remodeling. This protein is expressed in numerous cell types and may alos be involved in wound repair and regulate tumor growth and invasiveness. Mutations in this gene are the cause of short limb-hand type spondylometaepiphyseal dysplasia. [provided by RefSeq, Aug 2017]

• Gene Synonyms (MIG20a, NTRKR3, TKT, TYRO10, WRCN, discoidin domain-containing receptor 2, CD167 antigen-like family member B, cell migration-inducing protein 20, discoidin domain receptor 2, discoidin domain receptor family, member 2, discoidin domain-containing receptor tyrosine kinase 2, hydroxyaryl-protein kinase, migration-inducing gene 16 protein, neurotrophic tyrosine kinase receptor related 3, receptor protein-tyrosine kinase TKT, tyrosine-protein kinase TYRO10,)
• NCBI Gene ID: 4921
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R906
  UNIPROT ID#>>Q16832
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

discoidin domain receptor tyrosine kinase 2 interacts with:

• cysteine and histidine rich domain containing 1
  golgi transport 1B
  hepatitis A virus cellular receptor 1
  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
  protein tyrosine phosphatase 4A3
  ring finger protein 4
  SHC adaptor protein 1
  SRC proto-oncogene, non-receptor tyrosine kinase
  thiosulfate sulfurtransferase
  thymidine kinase 1
  vir like m6A methyltransferase associated

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.