PIK3CB, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta

PIK3CB, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta

• This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]

• Gene Synonyms (phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform, PI3-kinase p110 subunit beta, PI3-kinase subunit beta, PI3K-beta, PtdIns-3-kinase p110, phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta, phosphoinositide-3-kinase, catalytic, beta polypeptide, ptdIns-3-kinase subunit beta, ptdIns-3-kinase subunit p110-beta, P110BETA, PI3K, PI3KBETA, PIK3C1,)
• NCBI Gene ID: 5291
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B4DER4
  UNIPROT ID#>>B4DZI3
  UNIPROT ID#>>P42338
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta interacts with:

• calcium voltage-gated channel auxiliary subunit gamma 5
  dedicator of cytokinesis 5
  ETAA1 activator of ATR kinase
  fibronectin leucine rich transmembrane protein 1
  GRB2 associated binding protein 2
  hepatitis A virus cellular receptor 2
  HPS6 biogenesis of lysosomal organelles complex 2 subunit 3
  interleukin 20 receptor subunit alpha
  leucine rich repeat kinase 2
  MANSC domain containing 1
  mitogen-activated protein kinase kinase 2
  neuroligin 3
  phosphoinositide-3-kinase regulatory subunit 1
  phosphoinositide-3-kinase regulatory subunit 2
  phosphoinositide-3-kinase regulatory subunit 3
  Pim-1 proto-oncogene, serine/threonine kinase
  prolyl 4-hydroxylase subunit alpha 2
  prostaglandin E receptor 3
  protein kinase C delta
  protein kinase C epsilon
  RAB5A, member RAS oncogene family
  RAB5B, member RAS oncogene family
  Rap guanine nucleotide exchange factor 5
  ring finger protein 19B
  serine protease 8
  transforming growth factor beta receptor 2
  transmembrane protein 52B
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  WD repeat domain 26
  zinc finger DHHC-type containing 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.