OPA1, OPA1 mitochondrial dynamin like GTPase

OPA1, OPA1 mitochondrial dynamin like GTPase

• The protein encoded by this gene is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. The encoded protein localizes to the inner mitochondrial membrane and helps regulate mitochondrial stability and energy output. This protein also sequesters cytochrome c. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. [provided by RefSeq, Aug 2017]

• Gene Synonyms (BERHS, MGM1, MTDPS14, NPG, NTG, largeG, dynamin-like 120 kDa protein, mitochondrial, dynamin-like guanosine triphosphatase, mitochondrial dynamin-like GTPase, optic atrophy 1 (autosomal dominant), optic atrophy protein 1,)
• NCBI Gene ID: 4976
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O60313
  UNIPROT ID#>>E5KLJ9
  UNIPROT ID#>>E5KLK0
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

OPA1 mitochondrial dynamin like GTPase interacts with:

• 5'-3' exoribonuclease 2
  AAR2 splicing factor
  apolipoprotein O like
  apoptosis inducing factor mitochondria associated 1
  cellular communication network factor 1
  coenzyme Q9
  CTD phosphatase subunit 1
  cullin 3
  cullin associated and neddylation dissociated 1
  distal membrane arm assembly complex 1
  dual specificity phosphatase 22
  egl-9 family hypoxia inducible factor 3
  EH domain containing 1
  elongation factor Tu GTP binding domain containing 2
  family with sequence similarity 174 member A
  GID complex subunit 8 homolog
  HtrA serine peptidase 2
  inhibitory synaptic factor 2A
  LEO1 homolog, Paf1/RNA polymerase II complex component
  leucine rich repeat kinase 2
  limb development membrane protein 1 like
  membrane bound transcription factor peptidase, site 2
  mitochondrial contact site and cristae organizing system subunit 10
  nitrilase family member 2
  nuclear distribution C, dynein complex regulator
  nuclear receptor subfamily 2 group C member 2
  parathyroid hormone 1 receptor
  parkin RBR E3 ubiquitin protein ligase
  peroxiredoxin 3
  PHD finger protein 5A
  phosphopantothenoylcysteine synthetase
  PIH1 domain containing 1
  pitrilysin metallopeptidase 1
  plasminogen receptor with a C-terminal lysine
  pleckstrin homology domain containing A4
  prohibitin
  protein tyrosine phosphatase non-receptor type 7
  protein tyrosine phosphatase receptor type U
  PTEN induced kinase 1
  reactive oxygen species modulator 1
  RecQ like helicase 4
  Rho GTPase activating protein 17
  secretagogin, EF-hand calcium binding protein
  sideroflexin 1
  sodium voltage-gated channel beta subunit 2
  solute carrier family 25 member 46
  staufen double-stranded RNA binding protein 1
  synthesis of cytochrome C oxidase 1
  tafazzin
  translocase of inner mitochondrial membrane 22
  translocase of inner mitochondrial membrane 23 homolog B
  transmembrane phosphatase with tensin homology
  transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
  unk zinc finger
  vasoactive intestinal peptide receptor 2
  vir like m6A methyltransferase associated
  WD repeat domain 61
  X-ray repair cross complementing 3

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.