PRDX1, peroxiredoxin 1

PRDX1, peroxiredoxin 1

• This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Four transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jan 2011]

• Gene Synonyms (MSP23, NKEF-A, NKEFA, PAG, PAGA, PAGB, PRX1, PRXI, TDPX2, peroxiredoxin-1, epididymis secretory sperm binding protein, natural killer cell-enhancing factor A, natural killer-enhancing factor A, proliferation-associated gene A, proliferation-associated gene protein, thioredoxin peroxidase 2, thioredoxin-dependent peroxide reductase 2, thioredoxin-dependent peroxiredoxin 1,)
• NCBI Gene ID: 5052
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q06830
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

peroxiredoxin 1 interacts with:

• 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
  AAR2 splicing factor
  acetyl-CoA acyltransferase 2
  anaphase promoting complex subunit 15
  anterior gradient 2, protein disulphide isomerase family member
  argonaute RISC component 4
  ariadne RBR E3 ubiquitin protein ligase 2
  ATP synthase membrane subunit DAPIT
  beta-transducin repeat containing E3 ubiquitin protein ligase
  calcyclin binding protein
  cap methyltransferase 1
  cell division cycle 26
  cell division cycle 37, HSP90 cochaperone
  cell division cycle 73
  COP9 signalosome subunit 5
  COP9 signalosome subunit 6
  C-type lectin domain family 4 member G
  cullin 1
  cullin 2
  cullin 3
  cullin 4A
  cullin 4B
  cullin 5
  cullin 7
  cullin associated and neddylation dissociated 1
  cyclin-dependent kinase 1
  cytochrome c oxidase copper chaperone COX17
  DAZ associated protein 1
  DDB1 and CUL4 associated factor 4 like 2
  decapping enzyme, scavenger
  defective in cullin neddylation 1 domain containing 1
  developmental pluripotency-associated 3
  DExD-box helicase 39B
  dynactin 3
  egl-9 family hypoxia inducible factor 3
  elongation factor Tu GTP binding domain containing 2
  elongator complex protein 1
  eukaryotic translation initiation factor 4A3
  fascin actin-bundling protein 1
  fermitin family member 3
  G3BP stress granule assembly factor 1
  gigaxonin
  HECT domain E3 ubiquitin protein ligase 1
  HEXIM P-TEFb complex subunit 1
  IQ motif containing B1
  ISG15 ubiquitin like modifier
  La ribonucleoprotein 7, transcriptional regulator
  leucine aminopeptidase 3
  leucine rich repeat kinase 2
  LUC7 like
  macroH2A.1 histone
  methylphosphate capping enzyme
  methyltransferase like 14
  MT-RNR2 like 1
  myelocytomatosis oncogene
  myosin, heavy polypeptide 3, skeletal muscle, embryonic
  N-acetylneuraminate synthase
  neutrophil cytosolic factor 1
  nuclear receptor binding SET domain protein 2
  nuclear receptor subfamily 2 group C member 2
  obscurin like cytoskeletal adaptor 1
  OTU deubiquitinase, ubiquitin aldehyde binding 1
  p53-induced death domain protein 1
  palmitoyl-protein thioesterase 1
  parkin RBR E3 ubiquitin protein ligase
  peroxiredoxin 1
  peroxiredoxin 2
  peroxiredoxin 3
  peroxiredoxin 4
  peroxiredoxin 5
  peroxiredoxin 6
  phosphatase and tensin homolog
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  pre-mRNA processing factor 8
  prohibitin
  protein kinase C zeta
  protein kinase, DNA-activated, catalytic subunit
  protein phosphatase 1 catalytic subunit alpha
  protein phosphatase 2 regulatory subunit B'delta
  protein phosphatase 2 scaffold subunit Aalpha
  protein phosphatase 2 scaffold subunit Abeta
  PTEN induced kinase 1
  pyruvate dehyrogenase phosphatase catalytic subunit 1
  RAB4B, member RAS oncogene family
  RAD23 homolog A, nucleotide excision repair protein
  RAD52 homolog, DNA repair protein
  RecQ like helicase 4
  replication protein A1
  replication protein A2
  replication protein A3
  Rho/Rac guanine nucleotide exchange factor 2
  ribonuclease/angiogenin inhibitor 1
  ribosomal protein S6 kinase B2
  ring finger and CCCH-type domains 1
  ring finger protein 123
  ring finger protein 144A
  RIO kinase 1
  saccharopine dehydrogenase (putative)
  sepiapterin reductase
  sestrin 1
  sestrin 2
  SH2 domain containing 1B
  SH3 domain binding glutamate rich protein like 2
  SHC adaptor protein 1
  SKI proto-oncogene
  snail family transcriptional repressor 1
  SRY-box transcription factor 2
  superoxide dismutase 1
  SUZ12 polycomb repressive complex 2 subunit
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
  synuclein alpha
  telomeric repeat binding factor 1
  tet methylcytosine dioxygenase 2
  thioredoxin
  thymopoietin
  TIMELESS interacting protein
  TNF receptor associated factor 6
  TOR signaling pathway regulator
  torsin A interacting protein 1
  transketolase
  translin associated factor X
  transport and golgi organization 2 homolog
  tripartite motif containing 25
  tripartite motif containing 4
  tropomyosin 3
  tumor necrosis factor
  tumor protein p63
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  U2 small nuclear RNA auxiliary factor 2
  ubiquitin C
  ubiquitin conjugating enzyme E2 H
  ubiquitin conjugating enzyme E2 M
  ubiquitin C-terminal hydrolase L5
  ubiquitin like 4A
  ubiquitin protein ligase E3A
  ubiquitin related modifier 1
  ubiquitin specific peptidase 5
  vascular cell adhesion molecule 1
  vir like m6A methyltransferase associated
  von Hippel-Lindau tumor suppressor
  VRK serine/threonine kinase 3
  WT1 associated protein
  Yes1 associated transcriptional regulator
  zinc finger protein 598, E3 ubiquitin ligase
  zinc finger RNA binding protein

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.