PDE4B, phosphodiesterase 4B

PDE4B, phosphodiesterase 4B

• This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

• Gene Synonyms (cAMP-specific 3',5'-cyclic phosphodiesterase 4B, dunce-like phosphodiesterase E4, phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila), DPDE4, PDEIVB,)
• NCBI Gene ID: 5142
• Species: Homo sapiens (Human)
• UNIPROT ID#>>X5DNX5
  UNIPROT ID#>>X5DR82
  UNIPROT ID#>>Q68CX5
  UNIPROT ID#>>Q07343
  UNIPROT ID#>>Q59GM8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

phosphodiesterase 4B interacts with:

• DISC1 scaffold protein
  exportin 1
  nuclear RNA export factor 1
  phosphodiesterase 4D
  protein kinase cAMP-activated catalytic subunit alpha
  SMAD specific E3 ubiquitin protein ligase 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.