PDE4D, phosphodiesterase 4D

PDE4D, phosphodiesterase 4D

• This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.[provided by RefSeq, Sep 2009]

• Gene Synonyms (cAMP-specific 3',5'-cyclic phosphodiesterase 4D, cAMP-specific phosphodiesterase PDE4D6, phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila), testicular tissue protein Li 136, ACRDYS2, DPDE3, HSPDE4D, PDE43, PDE4DN2, STRK1,)
• NCBI Gene ID: 5144
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A140VJR0
  UNIPROT ID#>>Q08499
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

phosphodiesterase 4D interacts with:

• 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
  A-kinase anchoring protein 12
  A-kinase anchoring protein 6
  BUB1, mitotic checkpoint serine/threonine kinase
  centrosomal protein 152
  coilin
  dual specificity phosphatase 13
  F-box protein 7
  golgin A8 family member F
  HDGF like 2
  intersectin 1
  kinesin family member 13B
  mitogen-activated protein kinase 1
  PDZ and LIM domain 5
  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
  phosphodiesterase 4D
  phosphodiesterase 4D interacting protein
  phosphoinositide-3-kinase regulatory subunit 1
  polo like kinase 1
  protein inhibitor of activated STAT 4
  protein kinase cAMP-activated catalytic subunit alpha
  protein phosphatase 3 catalytic subunit alpha
  protein phosphatase 3 catalytic subunit beta
  protein phosphatase 3 regulatory subunit B, alpha
  protein tyrosine phosphatase, non-receptor type 13
  receptor for activated C kinase 1
  small ArfGAP 1
  smoothened, frizzled class receptor
  spectrin alpha, non-erythrocytic 1
  SRC proto-oncogene, non-receptor tyrosine kinase
  TNF receptor associated factor 1
  tripartite motif containing 25
  vir like m6A methyltransferase associated
  zinc finger and BTB domain containing 1
  zinc finger DHHC-type palmitoyltransferase 17

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.