PFKM, phosphofructokinase, muscle

PFKM, phosphofructokinase, muscle

• Three phosphofructokinase isozymes exist in humans: muscle, liver and platelet. These isozymes function as subunits of the mammalian tetramer phosphofructokinase, which catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-bisphosphate. Tetramer composition varies depending on tissue type. This gene encodes the muscle-type isozyme. Mutations in this gene have been associated with glycogen storage disease type VII, also known as Tarui disease. Alternatively spliced transcript variants have been described.[provided by RefSeq, Nov 2009]

• Gene Synonyms (ATP-dependent 6-phosphofructokinase, muscle type, 6-phosphofructo-1-kinase, 6-phosphofructokinase type A, 6-phosphofructokinase, muscle type, phosphofructo-1-kinase isozyme A, phosphofructokinase 1, phosphofructokinase, polypeptide X, phosphofructokinase-M, phosphohexokinase, protein phosphatase 1, regulatory subunit 122, ATP-PFK, GSD7, PFK-1, PFK-A, PFK1, PFKA, PFKX, PPP1R122,)
• NCBI Gene ID: 5213
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R0Y5
  UNIPROT ID#>>P08237
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

phosphofructokinase, muscle interacts with:

• ADP ribosylation factor interacting protein 1
  ADP ribosylation factor interacting protein 2
  argonaute RISC catalytic component 2
  ATPase H+ transporting V0 subunit a4
  aurora kinase A
  BCL2 like 14
  calcineurin like phosphoesterase domain containing 1
  centrosomal protein 78
  COMM domain containing 4
  cullin 3
  cytoskeleton associated protein 5
  decapping mRNA 1A
  decapping mRNA 2
  dynein light chain LC8-type 1
  egl-9 family hypoxia inducible factor 3
  elaC ribonuclease Z 2
  elongation factor Tu GTP binding domain containing 2
  exportin 6
  family with sequence similarity 98 member A
  F-box protein 6
  fermitin family member 2
  hepatocyte growth factor-regulated tyrosine kinase substrate
  histone PARylation factor 1
  homeobox A1
  hypoxia inducible factor 1 subunit alpha inhibitor
  LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated
  mitogen-activated protein kinase 1
  mitogen-activated protein kinase 3
  mitotic deacetylase associated SANT domain protein
  multiple coagulation factor deficiency 2, ER cargo receptor complex subunit
  ninein
  nuclear RNA export factor 1
  phosphatidylinositol binding clathrin assembly protein
  phosphofructokinase, muscle
  phosphofructokinase, platelet
  pleckstrin homology domain containing A4
  progesterone receptor membrane component 1
  prohibitin
  proline rich coiled-coil 1
  proteasome 26S subunit, non-ATPase 5
  proteasome assembly chaperone 1
  protein tyrosine phosphatase receptor type F
  pyruvate kinase M1/2
  receptor interacting serine/threonine kinase 4
  seryl-tRNA synthetase 1
  sestrin 2
  siah E3 ubiquitin protein ligase 1
  small ubiquitin like modifier 2
  small ubiquitin like modifier 3
  SNW domain containing 1
  splicing factor proline and glutamine rich
  TEA domain transcription factor 1
  TEA domain transcription factor 4
  tripartite motif containing 25
  tubulin alpha 1a
  tubulin beta 2A class IIa
  tubulin, gamma 1
  ubiquitin C
  ubiquitin domain containing 1
  UFM1 specific ligase 1
  vir like m6A methyltransferase associated
  YOD1 deubiquitinase
  zinc finger and BTB domain containing 7A
  zinc finger protein 746

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.