PHF1, PHD finger protein 1

PHF1, PHD finger protein 1

• This gene encodes a Polycomb group protein. The protein is a component of a histone H3 lysine-27 (H3K27)-specific methyltransferase complex, and functions in transcriptional repression of homeotic genes. The protein is also recruited to double-strand breaks, and reduced protein levels results in X-ray sensitivity and increased homologous recombination. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

• Gene Synonyms (PHD finger protein 1, hPCl1, polycomb-like 1, polycomb-like protein 1, testicular tissue protein Li 140, tudor domain containing 19C, MTF2L2, PCL1, PHF2, TDRD19C, hPHF1,)
• NCBI Gene ID: 5252
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A140VJR4
  UNIPROT ID#>>O43189
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

PHD finger protein 1 interacts with:

• abl interactor 2
  arginine vasopressin induced 1
  arrestin domain containing 3
  ataxin 7 like 1
  AT-rich interaction domain 4B
  AT-rich interaction domain 5A
  baculoviral IAP repeat containing 7
  basic helix-loop-helix family member b9
  basic helix-loop-helix family member e40
  boule homolog, RNA binding protein
  calcium binding and coiled-coil domain 2
  chaperonin containing TCP1 subunit 8
  chromosome 11 open reading frame 49
  cullin 4B
  DEK proto-oncogene
  DISC1 scaffold protein
  double PHD fingers 1
  EF-hand domain containing 2
  elongin BC and polycomb repressive complex 2 associated protein
  embryonic ectoderm development
  exosome component 4
  glutamate receptor interacting protein 1
  golgin A6 family like 9
  G-patch domain and KOW motifs
  H3 clustered histone 1
  H3 clustered histone 10
  H3 clustered histone 11
  H3 clustered histone 12
  H3 clustered histone 2
  H3 clustered histone 3
  H3 clustered histone 6
  H3 clustered histone 7
  H3 clustered histone 8
  H3.4 histone
  H4 clustered histone 1
  homeobox and leucine zipper encoding
  hydroxysteroid 17-beta dehydrogenase 14
  inhibitor of CDK, cyclin A1 interacting protein 1
  interleukin 1 receptor associated kinase 1 binding protein 1
  keratin 40
  KIAA0408
  ladybird homeobox 1
  leucine zipper tumor suppressor 2
  ligand dependent nuclear receptor corepressor
  LIM domain and actin binding 1
  lysine demethylase 1A
  MAGE family member D1
  metastasis associated 1
  metastasis associated 1 family member 2
  metastasis associated 1 family member 3
  MORN repeat containing 3
  natural cytotoxicity triggering receptor 1
  NIMA related kinase 6
  nuclear receptor coactivator 3
  PDZ and LIM domain 7
  PHD finger protein 1
  PHD finger protein 19
  POZ/BTB and AT hook containing zinc finger 1
  progesterone immunomodulatory binding factor 1
  proline and serine rich 2
  proline rich 20A
  proline rich 20B
  proline rich 20C
  proline rich 20D
  proline rich 20E
  protein arginine methyltransferase 5
  RAD50 double strand break repair protein
  RB binding protein 4, chromatin remodeling factor
  RB binding protein 7, chromatin remodeling factor
  RBBP8 N-terminal like
  ring-box 1
  RNA binding protein, mRNA processing factor
  RNA polymerase II subunit G
  SIN3 transcription regulator family member A
  Sin3A associated protein 30
  SMG9 nonsense mediated mRNA decay factor
  sorbin and SH3 domain containing 3
  sperm associated antigen 8
  SRC proto-oncogene, non-receptor tyrosine kinase
  structural maintenance of chromosomes 1A
  SUZ12 polycomb repressive complex 2 subunit
  tensin 2
  THAP domain containing 1
  TOX high mobility group box family member 2
  transcription factor CP2
  tuftelin interacting protein 11
  tumor protein p53
  tumor protein p53 binding protein 2
  ubiquitin specific peptidase 54
  VAC14 component of PIKFYVE complex
  WD repeat domain 77
  X-ray repair cross complementing 5
  zinc finger and BTB domain containing 10
  zinc finger and BTB domain containing 16
  zinc finger and SCAN domain containing 32
  zinc finger imprinted 2
  zinc finger protein 217
  zinc finger protein 500
  zinc finger protein 526
  zinc finger protein 688
  zinc finger protein 71
  zinc finger RANBP2-type containing 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.