PHKG2, phosphorylase kinase catalytic subunit gamma 2

PHKG2, phosphorylase kinase catalytic subunit gamma 2

• Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The beta subunit is the same in both the muscle and hepatic isoforms, and encoded by one gene. The gamma subunit also includes the skeletal muscle and hepatic isoforms, and the hepatic isoform is encoded by this gene. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9C, also known as autosomal liver glycogenosis. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]

• Gene Synonyms (phosphorylase b kinase gamma catalytic chain, liver/testis isoform, PHK-gamma-LT, PHK-gamma-T, PSK-C3, Phosphorylase kinase, gamma 2 (testis/liver), phosphorylase b kinase gamma catalytic chain, testis/liver isoform, phosphorylase kinase gamma subunit 2, phosphorylase kinase subunit gamma-2, phosphorylase kinase, gamma 2 (testis), serine/threonine-protein kinase PHKG2, GSD9C,)
• NCBI Gene ID: 5261
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P15735
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

phosphorylase kinase catalytic subunit gamma 2 interacts with:

• aminopeptidase puromycin sensitive
  ATPase family AAA domain containing 3A
  ATPase family AAA domain containing 3C
  basic leucine zipper and W2 domains 2
  catechol-O-methyltransferase domain containing 1
  centromere protein V
  centrosomal protein 85 like
  cytoplasmic linker associated protein 1
  docking protein 4
  EMAP like 4
  family with sequence similarity 171 member B
  forkhead box K1
  GCN1 activator of EIF2AK4
  general transcription factor IIIC subunit 5
  H3.5 histone
  HAUS augmin like complex subunit 2
  HECT and RLD domain containing E3 ubiquitin protein ligase 2
  HPS5 biogenesis of lysosomal organelles complex 2 subunit 2
  MAGE family member A2B
  mediator complex subunit 23
  myosin XIX
  NOP2/Sun RNA methyltransferase 4
  pleckstrin homology domain containing A4
  protein kinase AMP-activated catalytic subunit alpha 1
  protein kinase AMP-activated non-catalytic subunit beta 1
  protein kinase AMP-activated non-catalytic subunit beta 2
  protein kinase AMP-activated non-catalytic subunit gamma 1
  protein kinase AMP-activated non-catalytic subunit gamma 2
  protein kinase, DNA-activated, catalytic subunit
  protein phosphatase 1 regulatory subunit 3C
  protein phosphatase 1, regulatory subunit 3B
  Rac family small GTPase 1
  secretagogin, EF-hand calcium binding protein
  SET domain bifurcated histone lysine methyltransferase 1
  STIP1 homology and U-box containing protein 1
  synthesis of cytochrome C oxidase 2
  transcription elongation factor A N-terminal and central domain containing 2
  tumor protein p53
  ubiquitin protein ligase E3A
  valosin containing protein
  voltage dependent anion channel 2
  YME1 like 1 ATPase
  zinc finger CCCH-type containing 15

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.