POLA1, DNA polymerase alpha 1, catalytic subunit

POLA1, DNA polymerase alpha 1, catalytic subunit

• This gene encodes the catalytic subunit of DNA polymerase, which together with a regulatory and two primase subunits, forms the DNA polymerase alpha complex. The catalytic subunit plays an essential role in the initiation of DNA replication. [provided by RefSeq, Mar 2010]

• Gene Synonyms (DNA polymerase alpha catalytic subunit, DNA polymerase alpha catalytic subunit p180, polymerase (DNA directed), alpha 1, catalytic subunit, polymerase (DNA) alpha 1, catalytic subunit, polymerase (DNA-directed), alpha (70kD), NSX, POLA, VEODS, p180,)
• NCBI Gene ID: 5422
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P09884
  UNIPROT ID#>>A6NMQ1
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

DNA polymerase alpha 1, catalytic subunit interacts with:

• aldehyde dehydrogenase 1 family member L2
  BCL2-associated athanogene 2
  cell division cycle 45
  cyclin dependent kinase 2 associated protein 1
  cytosolic iron-sulfur assembly component 1
  DDB1 and CUL4 associated factor 4
  DNA helicase B
  DNA polymerase alpha 2, accessory subunit
  DNA polymerase delta 3, accessory subunit
  DNA polymerase epsilon 4, accessory subunit
  DNA polymerase epsilon, catalytic subunit
  DNA primase subunit 1
  DNA primase subunit 2
  elongation factor Tu GTP binding domain containing 2
  EMG1 N1-specific pseudouridine methyltransferase
  GINS complex subunit 4
  H3 clustered histone 1
  MAD2 mitotic arrest deficient-like 1
  membrane bound transcription factor peptidase, site 2
  MMS19 homolog, cytosolic iron-sulfur assembly component
  nuclear RNA export factor 1
  pleckstrin homology domain containing A4
  protein phosphatase 2 catalytic subunit alpha
  protein phosphatase 2 scaffold subunit Abeta
  purine rich element binding protein A
  RAB, member of RAS oncogene family like 2A
  RAD51 recombinase
  RB transcriptional corepressor 1
  replication protein A1
  replication protein A2
  replication protein A3
  ribonucleic acid export 1
  ribosomal protein L36a
  ring finger protein 123
  RNA binding motif single stranded interacting protein 1
  serine hydroxymethyltransferase 2
  sirtuin 7
  src kinase associated phosphoprotein 1
  staufen double-stranded RNA binding protein 1
  STN1 subunit of CST complex
  structural maintenance of chromosomes 1A
  suppressor of cytokine signaling 6
  transcription factor Dp family member 3
  tripartite motif containing 25
  tripartite motif containing 28
  tumor protein p53
  ubiquitin like modifier activating enzyme 2
  vir like m6A methyltransferase associated
  WD repeat and HMG-box DNA binding protein 1
  X-ray repair cross complementing 5

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.