PPP2CA, protein phosphatase 2 catalytic subunit alpha

PPP2CA, protein phosphatase 2 catalytic subunit alpha

• This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. [provided by RefSeq, Jul 2008]

• Gene Synonyms (serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, PP2A-alpha, protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform, protein phosphatase 2, catalytic subunit, alpha isozyme, replication protein C, serine/threonine protein phosphatase 2A, catalytic subunit, alpha isoform, NEDLBA, PP2Ac, PP2CA, PP2Calpha, RP-C,)
• NCBI Gene ID: 5515
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B3KUN1
  UNIPROT ID#>>P67775
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

protein phosphatase 2 catalytic subunit alpha interacts with:

• 5'-3' exoribonuclease 1
  AAR2 splicing factor
  Abelson helper integration site 1
  actin related protein 2/3 complex subunit 4
  adenosylhomocysteinase like 1
  adenylate cyclase 8
  A-kinase anchoring protein 6
  AKT serine/threonine kinase 3
  anaphase promoting complex subunit 1
  anaphase promoting complex subunit 4
  anaphase promoting complex subunit 7
  ankyrin repeat and LEM domain containing 2
  ATPase H+ transporting V1 subunit D
  aurora kinase B
  autophagy and beclin 1 regulator 1
  axin 1
  BAG cochaperone 3
  BCL10 immune signaling adaptor
  bestrophin 1
  BTB (POZ) domain containing 10
  calcium/calmodulin dependent protein kinase I
  caseinolytic mitochondrial matrix peptidase proteolytic subunit
  caspase recruitment domain family member 11
  CCAAT/enhancer binding protein (C/EBP), alpha
  CDC42 binding protein kinase beta
  cell division cycle associated 4
  centrosomal protein 131
  centrosomal protein 350
  centrosomal protein 43
  centrosomal protein 43
  chaperonin containing TCP1 subunit 2
  chaperonin containing TCP1 subunit 3
  chaperonin containing TCP1 subunit 4
  chaperonin containing TCP1 subunit 5
  chaperonin containing TCP1 subunit 7
  chaperonin containing TCP1 subunit 8
  checkpoint kinase 2
  chromobox 5
  coiled-coil domain containing 6
  COP1 E3 ubiquitin ligase
  COPI coat complex subunit epsilon
  cortactin binding protein 2
  CTD phosphatase subunit 1
  CTTNBP2 N-terminal like
  cullin 1
  cullin 3
  cullin 5
  cyclin G1
  D-dopachrome tautomerase like
  double PHD fingers 2
  dual specificity phosphatase 10
  dual specificity phosphatase 13
  dual specificity phosphatase 19
  dynein light chain LC8-type 1
  E1A binding protein p400
  egl-9 family hypoxia inducible factor 3
  elongation factor Tu GTP binding domain containing 2
  enhancer of polycomb homolog 1
  extra spindle pole bodies like 1, separase
  family with sequence similarity 122A
  family with sequence similarity 122B
  F-box and leucine rich repeat protein 16
  F-box protein 17
  FGFR1 oncogene partner 2
  forkhead box D4 like 6
  formin binding protein 1
  glycogen phosphorylase, muscle associated
  histone deacetylase 4
  histone deacetylase 5
  histone deacetylase 7
  inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
  inositol-3-phosphate synthase 1
  integrator complex subunit 1
  integrator complex subunit 10
  integrator complex subunit 11
  integrator complex subunit 12
  integrator complex subunit 14
  integrator complex subunit 2
  integrator complex subunit 3
  integrator complex subunit 4
  integrator complex subunit 5
  integrator complex subunit 6
  integrator complex subunit 7
  integrator complex subunit 8
  integrator complex subunit 9
  integrin alpha FG-GAP repeat containing 1
  kelch domain containing 8A
  kelch like family member 15
  kinase suppressor of ras 1
  KISS1 receptor
  L3MBTL histone methyl-lysine binding protein 3
  La ribonucleoprotein 7, transcriptional regulator
  laccase domain containing 1
  leucine carboxyl methyltransferase 1
  leucine rich repeat containing 56
  leucine rich repeat kinase 2
  ligand of numb-protein X 1
  mediator of DNA damage checkpoint 1
  mitochondrial ribosomal protein S26
  mitogen-activated protein kinase 1
  mitogen-activated protein kinase 3
  MOB family member 4, phocein
  NGG1 interacting factor 3 like 1
  NHL repeat containing 2
  NHS-like 1
  nitric oxide synthase interacting protein
  non-SMC condensin II complex subunit D3
  nuclear receptor subfamily 2 group C member 2
  nucleoredoxin
  nucleotide binding protein 2
  PAX interacting protein 1
  paxillin
  phosphofurin acidic cluster sorting protein 1
  PIH1 domain containing 1
  pirin
  pleckstrin homology domain containing A4
  pleiotrophin
  poly(A) binding protein cytoplasmic 1
  PR/SET domain 16
  programmed cell death 10
  proline rich 14
  proline rich 14 like
  proteasome 26S subunit, ATPase 6
  proteasome 26S subunit, non-ATPase 1
  proteasome 26S subunit, non-ATPase 3
  protein kinase AMP-activated catalytic subunit alpha 1
  protein kinase C delta
  protein kinase C zeta
  protein kinase N3
  protein kinase, DNA-activated, catalytic subunit
  protein phosphatase 2 catalytic subunit beta
  protein phosphatase 2 phosphatase activator
  protein phosphatase 2 regulatory subunit Balpha
  protein phosphatase 2 regulatory subunit B'alpha
  protein phosphatase 2 regulatory subunit B''alpha
  protein phosphatase 2 regulatory subunit Bbeta
  protein phosphatase 2 regulatory subunit B'beta
  protein phosphatase 2 regulatory subunit B''beta
  protein phosphatase 2 regulatory subunit Bdelta
  protein phosphatase 2 regulatory subunit B'delta
  protein phosphatase 2 regulatory subunit B'epsilon
  protein phosphatase 2 regulatory subunit Bgamma
  protein phosphatase 2 regulatory subunit B'gamma
  protein phosphatase 2 scaffold subunit Aalpha
  protein phosphatase 2 scaffold subunit Abeta
  protein phosphatase 2, regulatory subunit A, alpha
  protein phosphatase 2, regulatory subunit B'', alpha
  protein phosphatase 2, regulatory subunit B, delta
  protein phosphatase 4 catalytic subunit
  protein phosphatase 4 regulatory subunit 1
  protein phosphatase methylesterase 1
  protein tyrosine phosphatase domain containing 1
  protein tyrosine phosphatase non-receptor type 7
  PTPRF interacting protein alpha 1
  PTPRF interacting protein alpha 2
  PTPRF interacting protein alpha 3
  Rac family small GTPase 1
  Raf-1 proto-oncogene, serine/threonine kinase
  RAR related orphan receptor C
  RAS like proto-oncogene A
  RAS related
  RB transcriptional corepressor like 2
  receptor for activated C kinase 1
  RecQ like helicase 4
  RELA proto-oncogene, NF-kB subunit
  replication protein A1
  replication protein A2
  replication protein A3
  Rho/Rac guanine nucleotide exchange factor 2
  rhodopsin
  ribosomal protein S6 kinase B1
  ribosomal protein S6 kinase B2
  RIO kinase 1
  RP9 pre-mRNA splicing factor
  salt inducible kinase 2
  sarcolemma associated protein
  serine/threonine kinase 24
  serine/threonine kinase 25
  serine/threonine kinase 26
  SERTA domain containing 4
  serum/glucocorticoid regulated kinase 1
  SET binding protein 1
  SET nuclear proto-oncogene
  shugoshin 1
  shugoshin 2
  shugoshin 2A
  signal transducer and activator of transcription 5A
  signal transducer and activator of transcription 5B
  single-pass membrane protein with coiled-coil domains 3
  SMAD specific E3 ubiquitin protein ligase 1
  small RNA binding exonuclease protection factor La
  sprouty RTK signaling antagonist 2
  striatin
  striatin 3
  striatin 4
  striatin interacting protein 1
  striatin interacting protein 1
  striatin interacting protein 2
  striatin, calmodulin binding protein 3
  superoxide dismutase 1
  suppressor of glucose, autophagy associated 1
  suppressor of IKBKE 1
  TAFA chemokine like family member 3
  TBC1 domain family member 4
  TBCC domain containing 1
  t-complex 1
  telomeric repeat binding factor 1
  tetratricopeptide repeat domain 33
  thymoma viral proto-oncogene 3
  thyroid hormone receptor interactor 13
  TIAM Rac1 associated GEF 1
  TNF superfamily member 10
  TOR signaling pathway regulator
  TRAF3 interacting protein 3
  transformed mouse 3T3 cell double minute 2
  transportin 3
  tripartite motif containing 25
  tripartite motif containing 28
  tripartite motif containing 35
  TSC complex subunit 2
  tubulin alpha 8
  tubulin folding cofactor D
  tubulointerstitial nephritis antigen
  tumor protein p53
  twist family bHLH transcription factor 1
  ubiquitin associated protein 2
  ubiquitin specific peptidase 7
  unc-5 netrin receptor B
  unk zinc finger
  uracil DNA glycosylase
  URI1 prefoldin like chaperone
  VAC14 component of PIKFYVE complex
  vacuolar protein sorting 72 homolog
  valosin containing protein
  vascular cell adhesion molecule 1
  vitamin D receptor
  von Hippel-Lindau tumor suppressor
  WD repeat domain 61
  WD repeat domain 86
  Wnt family member 7A
  Yes1 associated transcriptional regulator
  yippee like 3
  ZFP36 ring finger protein
  zinc finger C3H1-type containing
  zinc finger protein 114
  zinc finger protein 217
  zinc finger protein 331
  zinc finger protein 346
  zinc finger protein 517
  zinc finger protein 550
  zinc finger protein 764
  zinc finger protein 785

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.