POLD2, DNA polymerase delta 2, accessory subunit

POLD2, DNA polymerase delta 2, accessory subunit

• This gene encodes the 50-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein is required for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclear antigen (PCNA). Expression of this gene may be a marker for ovarian carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Mar 2012]

• Gene Synonyms (DNA polymerase delta subunit 2, DAN polymerase delta 2, accessory subunit, DNA polymerase delta subunit p50, Pol delta B subunit (p50), polymerase (DNA directed), delta 2, accessory subunit, polymerase (DNA directed), delta 2, regulatory subunit 50kDa, polymerase (DNA) delta 2, accessory subunit,)
• NCBI Gene ID: 5425
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A087WWF6
  UNIPROT ID#>>P49005
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

DNA polymerase delta 2, accessory subunit interacts with:

• 5'-3' exoribonuclease 1
  archaelysin family metallopeptidase 1
  autophagy related 16 like 1
  coiled-coil alpha-helical rod protein 1
  dickkopf like acrosomal protein 1
  DISC1 scaffold protein
  DNA polymerase alpha 2, accessory subunit
  DNA polymerase delta 3, accessory subunit
  DNA polymerase delta 4, accessory subunit
  DNA polymerase delta interacting protein 2
  DNA polymerase delta interacting protein 3
  DNA polymerase eta
  endoplasmic reticulum protein 44
  exportin 1
  forkhead box K1
  H3 clustered histone 1
  LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated
  mitotic arrest deficient 2 like 2
  MMS19 homolog, cytosolic iron-sulfur assembly component
  MUS81 structure-specific endonuclease subunit
  niban apoptosis regulator 1
  nuclear receptor subfamily 2 group C member 2
  oxysterol binding protein like 9
  pleckstrin homology domain containing A4
  potassium channel tetramerization domain containing 13
  proliferating cell nuclear antigen
  prolyl 4-hydroxylase subunit alpha 2
  protein phosphatase 5 catalytic subunit
  RecQ like helicase 4
  REV3 like, DNA directed polymerase zeta catalytic subunit
  sirtuin 6
  SprT-like N-terminal domain
  SRY-box transcription factor 12
  tripartite motif containing 25
  WRN helicase interacting protein 1
  WRN RecQ like helicase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.