MAP2K6, mitogen-activated protein kinase kinase 6

MAP2K6, mitogen-activated protein kinase kinase 6

• This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. [provided by RefSeq, Jul 2008]

• Gene Synonyms (dual specificity mitogen-activated protein kinase kinase 6, MAPK/ERK kinase 6, MAPKK 6, MEK 6, SAPK kinase 3, protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6), stress-activated protein kinase kinase 3, MAPKK6, MEK6, MKK6, PRKMK6, SAPKK-3, SAPKK3,)
• NCBI Gene ID: 5608
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R8K3
  UNIPROT ID#>>P52564
  UNIPROT ID#>>A8K3Y2
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

mitogen-activated protein kinase kinase 6 interacts with:

• beclin 1
  F-box protein 31
  F-box protein 7
  GLIS family zinc finger 2
  leucine rich repeat kinase 2
  MAPK activated protein kinase 2
  mitogen-activated protein kinase 12
  mitogen-activated protein kinase 14
  mitogen-activated protein kinase kinase 4
  mitogen-activated protein kinase kinase 6
  mitogen-activated protein kinase kinase kinase 20
  mitogen-activated protein kinase kinase kinase 7
  phosphatase and tensin homolog
  pleckstrin homology domain containing A4
  protein interacting with PRKCA 1
  Raf-1 proto-oncogene, serine/threonine kinase
  Ras association domain family member 1
  receptor for activated C kinase 1
  RELA proto-oncogene, NF-kB subunit
  serine/threonine kinase 11
  signal transducer and activator of transcription 4
  TAO kinase 2
  TNF receptor associated factor 6
  toll like receptor 3
  zymogen granule protein 16B

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.