RANGAP1, Ran GTPase activating protein 1

RANGAP1, Ran GTPase activating protein 1

• This gene encodes a protein that associates with the nuclear pore complex and participates in the regulation of nuclear transport. The encoded protein interacts with Ras-related nuclear protein 1 (RAN) and regulates guanosine triphosphate (GTP)-binding and exchange. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

• Gene Synonyms (ran GTPase-activating protein 1, segregation distorter homolog, segregation distortion, Fug1, RANGAP, SD,)
• NCBI Gene ID: 5905
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P46060
  UNIPROT ID#>>A0A024R1U0
  UNIPROT ID#>>Q9BSK3
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

Ran GTPase activating protein 1 interacts with:

• actin related protein 2
  actin related protein 2/3 complex subunit 1B
  actin related protein 2/3 complex subunit 2
  actin related protein 3
  ATPase H+ transporting accessory protein 2
  BICD cargo adaptor 2
  BRISC and BRCA1 A complex member 1
  C-C motif chemokine ligand 5
  ceramide transporter 1
  chromosome 11 open reading frame 58
  cleavage and polyadenylation specific factor 1
  cleavage and polyadenylation specific factor 4
  CTD small phosphatase like 2
  C-type lectin domain containing 14A
  cullin 7
  DISC1 scaffold protein
  drebrin like
  dynactin 4
  dynein cytoplasmic 1 light intermediate chain 1
  dynein light chain roadblock-type 1
  egl-9 family hypoxia inducible factor 3
  elongation factor like GTPase 1
  elongation factor Tu GTP binding domain containing 2
  eukaryotic elongation factor 2 kinase
  exportin 1
  forkhead box B1
  forkhead box J3
  forkhead box Q1
  general transcription factor IIIC subunit 3
  golgi brefeldin A resistant guanine nucleotide exchange factor 1
  H2A clustered histone 4
  H4 clustered histone 1
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  importin 11
  importin 8
  kinesin family binding protein
  kinesin family member C1
  kinesin family member C5B
  limb development membrane protein 1 like
  lysine demethylase 2A
  methylphosphate capping enzyme
  mindbomb E3 ubiquitin protein ligase 1
  mitogen-activated protein kinase kinase kinase 13
  MMS19 homolog, cytosolic iron-sulfur assembly component
  myosin XVIIIA
  nemo like kinase
  NGG1 interacting factor 3 like 1
  NK2 homeobox 1
  NOP2/Sun RNA methyltransferase 2
  nuclear envelope integral membrane protein 1
  nuclear receptor coactivator 6
  nuclear RNA export factor 1
  nucleoporin 107
  nucleoporin 107
  nucleoporin 153
  nucleoporin 155
  nucleoporin 214
  nucleoporin 35
  nucleoporin 85
  nucleoporin 98
  obscurin like cytoskeletal adaptor 1
  O-sialoglycoprotein endopeptidase
  pantothenate kinase 4 (inactive)
  PCF11 cleavage and polyadenylation factor subunit
  peptidylprolyl isomerase F
  peroxiredoxin 6
  pleckstrin homology domain containing A4
  polo like kinase 1
  polycomb group ring finger 2
  polyribonucleotide nucleotidyltransferase 1
  pre-mRNA processing factor 8
  protein kinase, AMP-activated, alpha 1 catalytic subunit
  RALY heterogeneous nuclear ribonucleoprotein
  RAN binding protein 2
  Ran GTPase activating protein 1
  RANBP2 like and GRIP domain containing 2
  RANBP2 like and GRIP domain containing 5
  RANBP2 like and GRIP domain containing 6
  RecQ like helicase 4
  regulation of nuclear pre-mRNA domain containing 1B
  regulator of chromosome condensation 1
  rhomboid domain containing 1
  ring finger protein 123
  ring finger protein 2
  ring finger protein 4
  RNA polymerase III subunit C
  SEH1 like nucleoporin
  SH3 domain containing GRB2 like, endophilin B1
  sirtuin 7
  small ubiquitin like modifier 1
  small ubiquitin like modifier 2
  small ubiquitin like modifier 3
  SNW domain containing 1
  sorbitol dehydrogenase
  SPT5 homolog, DSIF elongation factor subunit
  SRY-box transcription factor 2
  SUB1 regulator of transcription
  SUMO specific peptidase 1
  SUMO specific peptidase 2
  SUMO/sentrin specific peptidase 2
  SUMO1 activating enzyme subunit 1
  suppressor of cytokine signaling 6
  TNFAIP3 interacting protein 2
  TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase
  TP53 regulating kinase
  TP53RK binding protein
  TPD52 like 2
  transcription factor 7 like 2
  transforming growth factor beta 1
  transmembrane and ubiquitin like domain containing 1
  tripartite motif containing 14
  tripartite motif containing 25
  tripartite motif containing 28
  tRNA-histidine guanylyltransferase 1 like
  U2 small nuclear RNA auxiliary factor 2
  ubiquitin conjugating enzyme E2 E3
  ubiquitin conjugating enzyme E2 I
  ubiquitin conjugating enzyme E2 M
  ubiquitin fold modifier 1
  ubiquitin protein ligase E3 component n-recognin 4
  ubiquitin protein ligase E3 component n-recognin 5
  ubiquitin specific peptidase like 1
  ubiquitin-conjugating enzyme E2I
  vir like m6A methyltransferase associated
  WD repeat domain 76

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.