RPS6KA3, ribosomal protein S6 kinase A3

RPS6KA3, ribosomal protein S6 kinase A3

• This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS). [provided by RefSeq, Jul 2008]

• Gene Synonyms (ribosomal protein S6 kinase alpha-3, MAP kinase-activated protein kinase 1b, MAPK-activated protein kinase 1b, MAPKAP kinase 1b, MAPKAPK-1b, RSK-2, S6K-alpha-3, epididymis secretory sperm binding protein, insulin-stimulated protein kinase 1, p90-RSK 3, ribosomal S6 kinase 2, ribosomal protein S6 kinase, 90kDa, polypeptide 3, CLS, HU-3, ISPK-1, MAPKAPK1B, MRX19, RSK, RSK2, S6K-alpha3, p90-RSK2, pp90RSK2,)
• NCBI Gene ID: 6197
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P51812
  UNIPROT ID#>>B4DG22
  UNIPROT ID#>>B7ZB17
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ribosomal protein S6 kinase A3 interacts with:

• 1-acylglycerol-3-phosphate O-acyltransferase 1
  aminopeptidase puromycin sensitive
  BARX homeobox 1
  cell division cycle 37, HSP90 cochaperone
  dedicator of cytokinesis 4
  eukaryotic translation initiation factor 3 subunit C
  F-box protein 7
  fibroblast growth factor receptor substrate 2
  G2 and S-phase expressed 1
  golgi associated, gamma adaptin ear containing, ARF binding protein 2
  GTP binding protein 1
  guanine deaminase
  H3 clustered histone 1
  H3.4 histone
  ILK associated serine/threonine phosphatase
  immunity related GTPase cinema
  interleukin 17 receptor A
  KDEL endoplasmic reticulum protein retention receptor 2
  lipase maturation factor 2
  listerin E3 ubiquitin protein ligase 1
  Max protein
  membrane associated guanylate kinase, WW and PDZ domain containing 1
  mitotic spindle positioning
  nicotinate phosphoribosyltransferase
  N-terminal glutamine amidase 1
  nuclear receptor subfamily 2 group C member 2
  nudE neurodevelopment protein 1 like 1
  pleckstrin homology domain containing A4
  proliferation and apoptosis adaptor protein 15
  protein phosphatase 6 regulatory subunit 2
  RAS protein activator like 1
  Rho guanine nucleotide exchange factor 12
  ribosomal protein S6 kinase A3
  scribble planar cell polarity protein
  serine/threonine kinase 11
  SET domain containing 3
  SH3 and multiple ankyrin repeat domains 1
  sideroflexin 2
  SLC9A3 regulator 1
  spermine synthase
  sprouty related EVH1 domain containing 2
  SRC proto-oncogene, non-receptor tyrosine kinase
  STE20 related adaptor beta
  stress induced phosphoprotein 1
  thymopoietin
  TNF receptor associated factor 2
  transglutaminase 2
  transmembrane protein 139
  tripartite motif containing 11
  tRNA methyltransferase 9B (putative)
  tumor protein p53
  ubiquitin conjugating enzyme E2 D3
  UTP18 small subunit processome component
  zinc finger MYM-type containing 5

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.