SAT1, spermidine/spermine N1-acetyltransferase 1

SAT1, spermidine/spermine N1-acetyltransferase 1

• The protein encoded by this gene belongs to the acetyltransferase family, and is a rate-limiting enzyme in the catabolic pathway of polyamine metabolism. It catalyzes the acetylation of spermidine and spermine, and is involved in the regulation of the intracellular concentration of polyamines and their transport out of cells. Defects in this gene are associated with keratosis follicularis spinulosa decalvans (KFSD). Alternatively spliced transcripts have been found for this gene.[provided by RefSeq, Sep 2009]

• Gene Synonyms (diamine acetyltransferase 1, diamine N-acetyltransferase 1, epididymis secretory sperm binding protein, polyamine N-acetyltransferase 1, putrescine acetyltransferase, spermidine/spermine N1-acetyltransferase alpha, DC21, KFSD, KFSDX, SAT, SSAT, SSAT-1,)
• NCBI Gene ID: 6303
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P21673
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

spermidine/spermine N1-acetyltransferase 1 interacts with:

• abhydrolase domain containing 15
  aspartyl aminopeptidase
  ATP binding cassette subfamily B member 8
  basic helix-loop-helix family member a9
  beta-1,4-galactosyltransferase 3
  CDC42 effector protein 1
  centrosomal protein 126
  chromosome 19 open reading frame 25
  coiled-coil alpha-helical rod protein 1
  coiled-coil domain containing 148
  coiled-coil domain containing 90B
  COP9 signalosome subunit 6
  DDB1 and CUL4 associated factor 15
  DExD-box helicase 39A
  diacylglycerol kinase zeta
  divergent protein kinase domain 1B
  doublesex and mab-3 related transcription factor 3
  ergosterol biosynthesis 28 homolog
  eukaryotic translation initiation factor 3 subunit D
  eva-1 homolog A, regulator of programmed cell death
  family with sequence similarity 156 member A
  family with sequence similarity 228 member A
  FtsJ RNA 2'-O-methyltransferase 3
  FUN14 domain containing 2
  growth arrest specific 2 like 2
  INO80 complex subunit C
  KH domain containing 4, pre-mRNA splicing factor
  ligand dependent nuclear receptor interacting factor 1
  ligand of numb-protein X 1
  LIM homeobox 3
  LUC7 like 2, pre-mRNA splicing factor
  LYR motif containing 7
  lysine acetyltransferase 5
  lysine acetyltransferase 7
  mediator complex subunit 31
  metastasis associated 1
  mitochondrial ribosomal protein L9
  Myb related transcription factor, partner of profilin
  NGG1 interacting factor 3 like 1
  nicotinamide riboside kinase 2
  N-terminal glutamine amidase 1
  peroxiredoxin 2
  plasminogen receptor with a C-terminal lysine
  receptor for activated C kinase 1
  ribonuclease P and MRP subunit p25
  RNA binding motif protein 17
  RNA binding motif protein 48
  selenophosphate synthetase 1
  SET domain bifurcated histone lysine methyltransferase 1
  snail family transcriptional repressor 2
  spermidine/spermine N1-acetyltransferase 1
  spermidine/spermine N1-acetyltransferase family member 2
  store-operated calcium entry associated regulatory factor
  TEA domain transcription factor 4
  testis expressed 43
  thioredoxin 2
  TLE family member 1, transcriptional corepressor
  transcription factor 25
  translational activator of cytochrome c oxidase I
  troponin I1, slow skeletal type
  TSC22 domain family member 4
  tubulin beta 2A class IIa
  tumor protein p53
  ubiquitin conjugating enzyme E2 D3
  unc-119 lipid binding chaperone
  USH1 protein network component harmonin binding protein 1
  UTP14A small subunit processome component
  vasodilator stimulated phosphoprotein
  vitamin K epoxide reductase complex subunit 1
  zinc fingers and homeoboxes 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.