CCL11, C-C motif chemokine ligand 11

CCL11, C-C motif chemokine ligand 11

• This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil-specific chemokine is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. [provided by RefSeq, Sep 2014]

• Gene Synonyms (eotaxin, chemokine (C-C motif) ligand 11, eosinophil chemotactic protein, eotaxin-1, small inducible cytokine subfamily A (Cys-Cys), member 11 (eotaxin), SCYA11,)
• NCBI Gene ID: 6356
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P51671
  UNIPROT ID#>>Q6I9T4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

C-C motif chemokine ligand 11 interacts with:

• atypical chemokine receptor 4
  C-C motif chemokine ligand 11
  C-C motif chemokine receptor 2
  nudix hydrolase 3
  triosephosphate isomerase 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.