BIK, BCL2 interacting killer

BIK, BCL2 interacting killer

• The protein encoded by this gene shares a critical BH3 domain with other death-promoting proteins, such as BID, BAK, BAD and BAX, that is required for its pro-apoptotic activity, and for interaction with anti-apoptotic members of the BCL2 family, and viral survival-promoting proteins. Since the activity of this protein is suppressed in the presence of survival-promoting proteins, it is suggested as a likely target for anti-apoptotic proteins. [provided by RefSeq, Sep 2011]

• Gene Synonyms (bcl-2-interacting killer, BCL2-interacting killer (apoptosis-inducing), apoptosis inducer NBK, apoptosis-inducing NBK, natural born killer, BIP1, BP4, NBK,)
• NCBI Gene ID: 638
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R4X6
  UNIPROT ID#>>Q13323
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

BCL2 interacting killer interacts with:

• adhesion G protein-coupled receptor E2
  adiponectin, C1Q and collagen domain containing
  ALG8 alpha-1,3-glucosyltransferase
  androgen induced 1
  ankyrin repeat domain 46
  basonuclin 1
  BCL2 interacting protein 3
  BCL2 like 10
  bone morphogenetic protein 10
  BRICHOS domain containing 5
  butyrophilin subfamily 2 member A2
  cAMP responsive element binding protein 3
  CD53 molecule
  CD72 molecule
  chromosome 14 open reading frame 180
  chromosome 3 open reading frame 52
  chromosome 4 open reading frame 3
  CKLF like MARVEL transmembrane domain containing 5
  CKLF like MARVEL transmembrane domain containing 7
  claudin 19
  cornichon family AMPA receptor auxiliary protein 1
  cornichon family AMPA receptor auxiliary protein 3
  cortexin 3
  CRK like proto-oncogene, adaptor protein
  C-X-C motif chemokine ligand 16
  cytochrome b5 type B
  cytochrome b561
  ELOVL fatty acid elongase 4
  ERGIC and golgi 3
  exocyst complex component 3 like 2
  FAM3 metabolism regulating signaling molecule C
  family with sequence similarity 209 member A
  family with sequence similarity 241 member B
  Fc fragment of IgG receptor Ia
  fetal and adult testis expressed 1
  glutamate metabotropic receptor 2
  glutathione peroxidase 8 (putative)
  insulin induced gene 2
  MCL1 apoptosis regulator, BCL2 family member
  membrane associated ring-CH-type finger 5
  membrane spanning 4-domains A13
  N-acetyltransferase 8 (putative)
  nuclear receptor subfamily 2 group F member 2
  nurim
  PBX homeobox 3
  phospholamban
  phospholipid phosphatase 4
  post-GPI attachment to proteins 2
  potassium calcium-activated channel subfamily N member 4
  progesterone receptor membrane component 1
  proteolipid protein 1
  proteolipid protein 2
  receptor accessory protein 4
  rhomboid like 3
  RUS family member 1
  S100 calcium binding protein A1
  SEC22 homolog A, vesicle trafficking protein
  secretory carrier membrane protein 4
  selenoprotein K
  small integral membrane protein 1 (Vel blood group)
  small transmembrane regulator of ion transport 1
  solute carrier family 35 member E3
  solute carrier family 37 member 4
  solute carrier family 39 member 7
  stress associated endoplasmic reticulum protein 1
  stress associated endoplasmic reticulum protein family member 2
  suppressor of cytokine signaling 3
  syntaxin 8
  TRAF family member associated NFKB activator
  trafficking regulator of GLUT4 (SLC2A4) 1
  translocator protein 2
  transmembrane BAX inhibitor motif containing 1
  transmembrane protein 107
  transmembrane protein 11
  transmembrane protein 14B
  transmembrane protein 14C
  transmembrane protein 199
  transmembrane protein 222
  transmembrane protein 229B
  transmembrane protein 243
  transmembrane protein 254
  transmembrane protein 60
  transmembrane protein 80
  transmembrane protein 86B
  transmembrane protein 97
  UbiA prenyltransferase domain containing 1
  vesicle associated membrane protein 3
  vesicle associated membrane protein 5
  zinc finger protein like 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.