CRKL, CRK like proto-oncogene, adaptor protein

CRKL, CRK like proto-oncogene, adaptor protein

• This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009]

• Gene Synonyms (crk-like protein, v-crk avian sarcoma virus CT10 oncogene homolog-like,)
• NCBI Gene ID: 1399
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P46109
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

CRK like proto-oncogene, adaptor protein interacts with:

• AAR2 splicing factor
  apoptosis resistant E3 ubiquitin protein ligase 1
  B cell linker
  BAG cochaperone 3
  BCAR1 scaffold protein, Cas family member
  centrosomal protein 170
  chloride intracellular channel 4
  cryptochrome circadian regulator 2
  cullin 7
  DAB adaptor protein 1
  DEAD-box helicase 6
  decapping mRNA 1A
  decapping mRNA 2
  dedicator of cytokinesis 1
  dedicator of cytokinesis 2
  dedicator of cytokinesis 5
  docking protein 1
  docking protein 2
  dynamin 2
  egl-9 family hypoxia inducible factor 3
  ELAV like RNA binding protein 1
  elongation factor Tu GTP binding domain containing 2
  Enah/Vasp-like
  engulfment and cell motility 2
  enhancer of mRNA decapping 3
  enhancer of mRNA decapping 4
  EPH receptor B6
  epidermal growth factor receptor
  epidermal growth factor receptor pathway substrate 15
  erb-b2 receptor tyrosine kinase 2
  erb-b2 receptor tyrosine kinase 3
  erythropoietin receptor
  ETS variant transcription factor 6
  EYA transcriptional coactivator and phosphatase 4
  Fc fragment of IgG receptor Ia
  fibroblast growth factor receptor 1
  golgi brefeldin A resistant guanine nucleotide exchange factor 1
  golgin, RAB6 interacting
  granulin precursor
  GRB2 associated binding protein 1
  GRB2 associated binding protein 2
  GRB2 associated regulator of MAPK1 subtype 1
  growth factor receptor bound protein 2
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  heterogeneous nuclear ribonucleoprotein H2
  huntingtin interacting protein 1 related
  impact RWD domain protein
  inositol polyphosphate-5-phosphatase D
  insulin like growth factor 1 receptor
  insulin receptor
  insulin receptor substrate 4
  integrin subunit beta 1
  interferon alpha and beta receptor subunit 1
  interferon induced protein with tetratricopeptide repeats 5
  KH RNA binding domain containing, signal transduction associated 1
  kinase D interacting substrate 220
  KIT proto-oncogene, receptor tyrosine kinase
  lamin A/C
  laminin subunit alpha 5
  latent transforming growth factor beta binding protein 4
  leucine rich repeat kinase 2
  LYN proto-oncogene, Src family tyrosine kinase
  lysine demethylase 6B
  meiosis regulator and mRNA stability factor 1
  minichromosome maintenance complex component 2
  mitogen-activated protein kinase kinase kinase kinase 1
  mitogen-activated protein kinase kinase kinase kinase 5
  Mov10 RISC complex RNA helicase
  MSL complex subunit 1
  multiple EGF like domains 6
  myelin protein zero like 1
  neural precursor cell expressed, developmentally down-regulated 9
  neurotrophic receptor tyrosine kinase 1
  ninein like
  notch receptor 2
  nuclear RNA export factor 1
  O-linked N-acetylglucosamine (GlcNAc) transferase
  OTU deubiquitinase, ubiquitin aldehyde binding 1
  outer dense fiber of sperm tails 2
  paxillin
  PEAK1 related, kinase-activating pseudokinase 1
  phosphatase and tensin homolog
  phosphoinositide-3-kinase regulatory subunit 1
  phosphoinositide-3-kinase regulatory subunit 2
  phospholipid scramblase 1
  PIH1 domain containing 1
  platelet derived growth factor receptor alpha
  pleckstrin homology domain containing A1
  pleckstrin homology domain containing A4
  polyhomeotic homolog 2
  PPFIA binding protein 2
  pre-mRNA processing factor 8
  programmed cell death 6
  proline rich 3
  proline rich nuclear receptor coactivator 1
  proteasome 26S subunit, ATPase 6
  protein tyrosine phosphatase domain containing 1
  protein tyrosine phosphatase non-receptor type 11
  protein tyrosine phosphatase non-receptor type 4
  pseudopodium enriched atypical kinase 1
  Rap guanine nucleotide exchange factor 1
  Ras and Rab interactor 3
  RecQ like helicase 4
  Rho GTPase activating protein 32
  Rho guanine nucleotide exchange factor 5
  ribosomal protein L31
  RNA polymerase I and III subunit D
  SAM and SH3 domain containing 1
  selenophosphate synthetase 1
  SH3 and multiple ankyrin repeat domains 3
  SHC adaptor protein 1
  signal transducer and activator of transcription 5A
  signal transducer and activator of transcription 5B
  SOS Ras/Rac guanine nucleotide exchange factor 1
  SOS Ras/Rho guanine nucleotide exchange factor 2
  spleen associated tyrosine kinase
  staufen double-stranded RNA binding protein 1
  suppressor of cytokine signaling 1
  telomere maintenance 2
  tensin 2
  TNF receptor associated protein 1
  transforming growth factor beta 1 induced transcript 1
  transmembrane protein 168
  tripartite motif containing 14
  tyrosine kinase 2
  tyrosine kinase non receptor 2
  ubiquitin conjugating enzyme E2 M
  ubiquitin like 5
  ubiquitin specific peptidase 53
  ubiquitin specific peptidase 7
  WAS/WASL interacting protein family member 1
  WASP actin nucleation promoting factor
  WW domain containing adaptor with coiled-coil
  X-ray repair cross complementing 6
  YES proto-oncogene 1, Src family tyrosine kinase
  YY1 transcription factor
  zeta chain of T cell receptor associated protein kinase 70

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.