BLMH, bleomycin hydrolase

BLMH, bleomycin hydrolase

• Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution; however, the only known activity of the enzyme is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. The protein contains the signature active site residues of the cysteine protease papain superfamily. [provided by RefSeq, Jul 2008]

• Gene Synonyms (bleomycin hydrolase, BLM hydrolase, BH, BMH,)
• NCBI Gene ID: 642
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q13867
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

bleomycin hydrolase interacts with:

• 3-phosphoinositide dependent protein kinase 1
  6-phosphogluconolactonase
  adaptor related protein complex 1 subunit mu 2
  AKT interacting protein
  anillin actin binding protein
  atlastin GTPase 3
  BAG cochaperone 6
  bleomycin hydrolase
  breast cancer 1, early onset
  CF transmembrane conductance regulator
  coiled-coil domain containing 8
  COP9 signalosome subunit 5
  cullin 4B
  CYLD lysine 63 deubiquitinase
  cytochrome P450 family 2 subfamily C member 8
  cytoskeleton associated protein 5
  dynein cytoplasmic 1 light intermediate chain 1
  ECSIT signaling integrator
  FA complementation group D2
  G3BP stress granule assembly factor 1
  general transcription factor IIA subunit 1
  glucose-6-phosphate dehydrogenase
  golgi reassembly stacking protein 2
  HECT and RLD domain containing E3 ubiquitin protein ligase 2
  heterogeneous nuclear ribonucleoprotein D
  HRas proto-oncogene, GTPase
  kelch repeat and BTB domain containing 7
  keratocan
  leucine zipper transcription factor like 1
  LIM domain kinase 1
  methyltransferase like 14
  microtubule associated protein RP/EB family member 1
  microtubule associated serine/threonine kinase 1
  minichromosome maintenance complex component 2
  mitogen-activated protein kinase 8
  MYC proto-oncogene, bHLH transcription factor
  N(alpha)-acetyltransferase 10, NatA catalytic subunit
  N-terminal glutamine amidase 1
  nuclear RNA export factor 1
  nudix hydrolase 12
  pescadillo ribosomal biogenesis factor 1
  protein phosphatase 6, regulatory subunit 1
  protein tyrosine phosphatase 4A1
  protocadherin beta 15
  RecQ like helicase 4
  reticulophagy regulator family member 2
  ribosomal protein L11
  ribosomal protein L29
  ring finger protein 32
  SET domain, bifurcated 1
  SH3 domain containing GRB2 like, endophilin B2
  signal peptidase complex subunit 2 homolog (S. cerevisiae)
  small glutamine rich tetratricopeptide repeat containing beta
  sortilin 1
  synaptotagmin binding cytoplasmic RNA interacting protein
  TATA-box binding protein associated factor 15
  TATA-box binding protein associated factor 15
  tectonin beta-propeller repeat containing 2
  torsin A interacting protein 1
  transforming growth factor, beta receptor I
  transportin 2
  transportin 3
  trio Rho guanine nucleotide exchange factor
  tripartite motif containing 25
  tripartite motif containing 47
  tubulin, alpha 3A
  ubiquilin 2
  ubiquitin conjugating enzyme E2 I
  ubiquitin specific peptidase 53
  ubiquitin specific peptidase 7
  WT1 associated protein
  zinc finger and BTB domain containing 1
  zinc finger containing ubiquitin peptidase 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.