SKIV2L, Ski2 like RNA helicase

SKIV2L, Ski2 like RNA helicase

• DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a human homologue of yeast SKI2 and may be involved in antiviral activity by blocking translation of poly(A) deficient mRNAs. This gene is located in the class III region of the major histocompatibility complex. [provided by RefSeq, Jul 2008]

• Gene Synonyms (helicase SKI2W, SKI2 homolog, superkiller viralicidic activity 2-like, helicase-like protein, superkiller viralicidic activity 2-like, 170A, DDX13, HLP, SKI2, SKI2W, SKIV2, SKIV2L1, THES2,)
• NCBI Gene ID: 6499
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q15477
  UNIPROT ID#>>A0A1U9X8J1
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

Ski2 like RNA helicase interacts with:

• 2'-5'-oligoadenylate synthetase like
  5'-3' exoribonuclease 1
  Aly/REF export factor
  cyclic GMP-AMP synthase
  cyclin dependent kinase 11A
  cyclin dependent kinase like 5
  cyclin K
  dual specificity phosphatase 10
  eukaryotic translation initiation factor 3, subunit A
  exosome component 4
  fermitin family member 1
  HMG-box transcription factor 1
  LEO1 homolog, Paf1/RNA polymerase II complex component
  leucine rich repeat containing G protein-coupled receptor 4
  limb development membrane protein 1 like
  mitogen-activated protein kinase kinase kinase 14
  NADPH dependent diflavin oxidoreductase 1
  nuclear receptor subfamily 2 group C member 2
  pelota mRNA surveillance and ribosome rescue factor
  peptidase, mitochondrial processing subunit alpha
  pleckstrin homology domain containing A4
  polypeptide N-acetylgalactosaminyltransferase 13
  protein tyrosine phosphatase mitochondrial 1
  RAB4B, member RAS oncogene family
  ras homolog family member U
  ribosomal protein L35
  ribosome binding protein 1
  sirtuin 7
  Ski2 like RNA helicase
  small nuclear ribonucleoprotein polypeptides B and B1
  small nuclear RNA activating complex polypeptide 1
  staufen double-stranded RNA binding protein 1
  testin LIM domain protein
  testis specific serine kinase 2
  tetratricopeptide repeat domain 37
  transcription activation suppressor
  ubiquitin like modifier activating enzyme 2
  vir like m6A methyltransferase associated
  WD repeat domain 1
  WW domain containing E3 ubiquitin protein ligase 2
  zinc finger protein 746

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.