SOX10, SRY-box transcription factor 10

SOX10, SRY-box transcription factor 10

• This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease. [provided by RefSeq, Jul 2008]

• Gene Synonyms (transcription factor SOX-10, SRY (sex determining region Y)-box 10, SRY-box 10, SRY-related HMG-box gene 10, dominant megacolon, mouse, human homolog of, DOM, PCWH, WS2E, WS4, WS4C,)
• NCBI Gene ID: 6663
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R1N6
  UNIPROT ID#>>P56693
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

SRY-box transcription factor 10 interacts with:

• ALX homeobox 4
  chromodomain helicase DNA binding protein 7
  DAZ associated protein 2
  exocyst complex component 5
  F-box and WD repeat domain containing 7
  MAGE family member D1
  N-myc and STAT interactor
  oligodendrocyte transcription factor 2
  OTU deubiquitinase, ubiquitin aldehyde binding 2
  paired related homeobox 2
  POU class 6 homeobox 2
  small ubiquitin like modifier 1
  Sp1 transcription factor
  SRY-box transcription factor 10
  transcription factor 12
  ubiquitin conjugating enzyme E2 I
  undifferentiated embryonic cell transcription factor 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.