TBP, TATA-box binding protein

TBP, TATA-box binding protein

• Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. The number of CAG repeats encoding the polyglutamine tract is usually 25-42, and expansion of the number of repeats to 45-66 increases the length of the polyglutamine string and is associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2016]

• Gene Synonyms (TATA-box-binding protein, TATA sequence-binding protein, TATA-box binding protein N-terminal domain, TATA-box factor, transcription initiation factor TFIID TBP subunit, GTF2D, GTF2D1, HDL4, SCA17, TFIID,)
• NCBI Gene ID: 6908
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P20226
  UNIPROT ID#>>Q32MN7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

TATA-box binding protein interacts with:

• activator of basal transcription 1
  activator of basal transcription 1
  BRF2 RNA polymerase III transcription initiation factor subunit
  B-TFIID TATA-box binding protein associated factor 1
  cadherin 1
  Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2
  CCCTC-binding factor like
  cellular repressor of E1A stimulated genes 1
  centrin 2
  charged multivesicular body protein 6
  chromobox 5
  cleavage and polyadenylation specific factor 1
  cleavage and polyadenylation specific factor 2
  cleavage and polyadenylation specific factor 3
  collagen type XXVI alpha 1 chain
  CUE domain containing 2
  cullin associated and neddylation dissociated 2 (putative)
  CXXC finger protein 1
  DR1 associated protein 1
  endothelial differentiation related factor 1
  fetal and adult testis expressed 1
  forkhead box J2
  forkhead box N1
  forkhead box P1
  G protein subunit gamma 12
  general transcription factor IIA subunit 1 like
  general transcription factor IIIC subunit 3
  general transcription factor IIIC subunit 4
  general transcription factor IIIC subunit 5
  H3 clustered histone 1
  H3.4 histone
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  homeobox containing 1
  huntingtin associated protein 1
  IKAROS family zinc finger 1
  interactor of little elongation complex ELL subunit 2
  KIAA1143
  leucine rich repeat containing 46
  mediator complex subunit 26
  methyl-CpG binding domain protein 2
  mohawk homeobox
  non-SMC condensin I complex subunit H
  nuclear assembly factor 1 ribonucleoprotein
  nuclear receptor coactivator 1
  nuclear receptor coactivator 3
  nuclear receptor coactivator 6
  proteasome activator subunit 3
  protein inhibitor of activated STAT 1
  protein inhibitor of activated STAT 3
  RecQ like helicase 4
  ring finger protein 168
  RNA polymerase I subunit G
  RNA polymerase III subunit C
  RNA polymerase III subunit F
  RRN3 homolog, RNA polymerase I transcription factor
  RuvB like AAA ATPase 1
  RuvB like AAA ATPase 2
  SET domain containing 7, histone lysine methyltransferase
  SIN3 transcription regulator family member A
  SSX family member 2 interacting protein
  SUB1 regulator of transcription
  TATA-box binding protein
  TATA-box binding protein associated factor 1 like
  TATA-box binding protein associated factor 3
  TATA-box binding protein associated factor 7 like
  TATA-box binding protein associated factor 8
  TATA-box binding protein associated factor 9b
  TATA-box binding protein associated factor, RNA polymerase I subunit A
  TATA-box binding protein associated factor, RNA polymerase I subunit B
  TATA-box binding protein associated factor, RNA polymerase I subunit C
  TATA-box binding protein associated factor, RNA polymerase I subunit D
  TATA-box binding protein associated factor, RNA polymerase I, A
  TATA-box binding protein associated factor, RNA polymerase I, B
  TATA-box binding protein associated factor, RNA polymerase I, C
  TATA-box binding protein like 1
  TEA domain transcription factor 1
  thyroid hormone receptor interactor 4
  transcription elongation factor A1
  transcription factor 12
  transcription factor 7 like 2
  transcriptional regulator, SIN3A (yeast)
  translocation associated membrane protein 2
  tumor protein p53
  ubiquitin conjugating enzyme E2 I
  ubiquitin specific peptidase 10
  upstream binding transcription factor
  vacuolar protein sorting 28
  WD repeat domain 62
  YEATS domain containing 2
  zinc finger protein 76

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.