TEC, tec protein tyrosine kinase

TEC, tec protein tyrosine kinase

• The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome. [provided by RefSeq, Jul 2008]

• Gene Synonyms (tyrosine-protein kinase Tec, PSCTK4,)
• NCBI Gene ID: 7006
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P42680
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

tec protein tyrosine kinase interacts with:

• F-box protein 7
  G protein subunit alpha 13
  inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
  leucine rich repeat kinase 1
  mediator complex subunit 28
  phosphatidylinositol-4-phosphate 5-kinase type 1 alpha
  phosphoinositide-3-kinase regulatory subunit 3
  polo like kinase 4
  protein tyrosine phosphatase non-receptor type 18
  protein tyrosine phosphatase non-receptor type 21
  Rho guanine nucleotide exchange factor 12
  signal transducing adaptor family member 1
  suppressor of cytokine signaling 1
  tec protein tyrosine kinase
  tumor protein p53
  vav guanine nucleotide exchange factor 1
  WASP actin nucleation promoting factor

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.