TEK, TEK receptor tyrosine kinase

TEK, TEK receptor tyrosine kinase

• This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]

• Gene Synonyms (angiopoietin-1 receptor, TEK tyrosine kinase, endothelial, endothelial tyrosine kinase, tunica interna endothelial cell kinase, tyrosine kinase with Ig and EGF homology domains-2, tyrosine-protein kinase receptor TEK, tyrosine-protein kinase receptor TIE-2, CD202B, GLC3E, TIE-2, TIE2, VMCM, VMCM1,)
• NCBI Gene ID: 7010
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q02763
  UNIPROT ID#>>Q59HG2
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

TEK receptor tyrosine kinase interacts with:

• angiopoietin 4
  angiopoietin like 1
  docking protein 2
  docking protein 4
  dual specificity phosphatase 18
  ILK associated serine/threonine phosphatase
  inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
  suppressor of cytokine signaling 1
  TEK receptor tyrosine kinase
  TNFAIP3 interacting protein 2
  tyrosine kinase with immunoglobulin like and EGF like domains 1

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