TIMP3, TIMP metallopeptidase inhibitor 3

TIMP3, TIMP metallopeptidase inhibitor 3

• This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy. [provided by RefSeq, Jul 2008]

• Gene Synonyms (metalloproteinase inhibitor 3, MIG-5 protein, TIMP-3, protein MIG-5, tissue inhibitor of metalloproteinases 3, HSMRK222, K222, K222TA2, SFD,)
• NCBI Gene ID: 7078
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P35625
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

TIMP metallopeptidase inhibitor 3 interacts with:

• ADP dependent glucokinase
  collectin subfamily member 10
  collectin subfamily member 11
  dickkopf WNT signaling pathway inhibitor 3
  family with sequence similarity 136 member A
  IFI30 lysosomal thiol reductase
  killer cell lectin like receptor G2
  pleckstrin homology domain containing A4
  proprotein convertase subtilisin/kexin type 5
  von Willebrand factor C and EGF domains
  zinc finger containing ubiquitin peptidase 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.